Cell Biology Antibodies 15

Anti-KDM2A Antibody (CAB18636)

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SKU:
CAB18636
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-KDM2A Antibody
Antibody SKU:CAB18636
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human KDM2A.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant protein of human KDM2A.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:22992
Uniprot:Q9Y2K7
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:
Background:
UniProt Protein Function:FBXL11: Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Belongs to the JHDM1 histone demethylase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 1.14.11.27; Demethylase; Oxidoreductase

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: nucleolus; nucleoplasm; nucleus

Molecular Function:histone demethylase activity

Biological Process: double-strand break repair via nonhomologous end joining

NCBI Summary:This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
UniProt Code:Q9Y2K7
NCBI GenInfo Identifier:38257795
NCBI Gene ID:22992
NCBI Accession:Q9Y2K7.3
UniProt Secondary Accession:Q9Y2K7,Q49A21, Q4G0M3, Q69YY8, Q9BVH5, Q9H7H5, Q9UK66 D4QA03, E9PIL6, I3VM55,
UniProt Related Accession:Q9Y2K7
Molecular Weight:89,948 Da
NCBI Full Name:Lysine-specific demethylase 2A
NCBI Synonym Full Names:lysine demethylase 2A
NCBI Official Symbol:KDM2A  
NCBI Official Synonym Symbols:FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA  
NCBI Protein Information:lysine-specific demethylase 2A
UniProt Protein Name:Lysine-specific demethylase 2A
UniProt Synonym Protein Names:CXXC-type zinc finger protein 8; F-box and leucine-rich repeat protein 11; F-box protein FBL7; F-box protein Lilina; F-box/LRR-repeat protein 11; JmjC domain-containing histone demethylation protein 1A; [Histone-H3]-lysine-36 demethylase 1A
Protein Family:Lysine-specific demethylase
UniProt Gene Name:KDM2A  
UniProt Entry Name:KDM2A_HUMAN
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