Anti-KDELR1 Antibody (CAB20343)

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SKU:
CAB20343
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ERD2
Synonyms:
HDEL
Synonyms:
PM23
Synonyms:
ERD2.1

Description

Product Name:KDELR1 Rabbit pAb
Product Code:CAB20343
Size:50uL, 100uL
Synonyms:ERD2, HDEL, PM23, ERD2.1
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 40-100 of human KDELR1 (NP_006792.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 40-100 of human KDELR1 (NP_006792.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10945
Uniprot:P24390
Calculated MW:24kDa
Observed MW:Refer to figures
Background:Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.
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