Signal Transduction Antibodies 1

Anti-KCTD10 Antibody (CAB11941)

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SKU:
CAB11941
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-KCTD10 Antibody
Antibody SKU:CAB11941
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human KCTD10 (NP_114160.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, HeLa, Jurkat, MCF7, Mouse brain, Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human KCTD10 (NP_114160.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEEM SGES VVSS AVPA AATR TTSF KGTS PSSK YVKL NVGG ALYY TTMQ TLTK QDTM LKAM FSGR MEVL TDSE GWIL IDRC GKHF GTIL NYLR DGAV PLPE SRRE IEEL LAEA KYYL VQGL VEEC QAAL QNKD TYEP FCKV PVIT SSKE EQKL IATS NKPA
Gene ID:83892
Uniprot:Q9H3F6
Cellular Location:Nucleus
Calculated MW:17kDa/32kDa/35kDa
Observed MW:36kDa
Synonyms:KCTD10, BTBD28, MSTP028, ULRO61, hBACURD3
Background:The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene.
UniProt Protein Function:KCTD10: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. Belongs to the BACURD family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: nucleoplasm; cytoplasm

Molecular Function:ubiquitin-protein ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; protein homooligomerization

UniProt Code:Q9H3F6
NCBI GenInfo Identifier:74733570
NCBI Gene ID:83892
NCBI Accession:Q9H3F6.1
UniProt Secondary Accession:Q9H3F6,Q53HN2, Q59FV1, Q6PL47, Q96SU0,
UniProt Related Accession:Q9H3F6
Molecular Weight:17,985 Da
NCBI Full Name:BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
NCBI Synonym Full Names:potassium channel tetramerization domain containing 10
NCBI Official Symbol:KCTD10  
NCBI Official Synonym Symbols:BTBD28; ULRO61; MSTP028; hBACURD3  
NCBI Protein Information:BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; BTB/POZ domain-containing protein KCTD10; potassium channel tetramerisation domain containing 10; potassium channel tetramerization domain-containing protein 10
UniProt Protein Name:BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
UniProt Synonym Protein Names:BTB/POZ domain-containing protein KCTD10; Potassium channel tetramerization domain-containing protein 10
Protein Family:BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein
UniProt Gene Name:KCTD10  
UniProt Entry Name:BACD3_HUMAN
Anti-KCTD10 Antibody (CAB11941)Western blot analysis of extracts of various cell lines, using KCTD10 antibody (CAB11941) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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