Signal Transduction Antibodies 2

Anti-KCNU1 Antibody (CAB14967)

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SKU:
CAB14967
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-KCNU1 Antibody
Antibody SKU:CAB14967
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 920-1149 of human KCNU1 (NP_001027006.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 920-1149 of human KCNU1 (NP_001027006.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LELL QMLV TGGV SSQL EQHL DKDK VYGV ADSC TSLL SGRN RCKL GLLS LHET ILSD VNPR NTFG QLFC GSLD LFGI LCVG LYRI IDEE ELNP ENKR FVIT RPAN EFKL LPSD LVFC AIPF STAC YKRN EEFS LQKS YEIV NKAS QTTE THSD TNCP PTID SVTE TLYS PVYS YQPR TNSL SFPK QIAW NQSR TNSI ISSQ IPLG DNAK ENER KTSD EVYD EDPF AYSE PL
Gene ID:157855
Uniprot:A8MYU2
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:129kDa
Observed MW:130kDa
Synonyms:KCNU1, KCNMC1, KCa5, KCa5.1, Kcnma3, Slo3
Background:This gene encodes a member of the potassium channel family of proteins. The encoded voltage-gated ion channel allows the outward flow of potassium ions during plasma membrane hyperpolarization in sperm. Opening of this channel may be regulated by calcium ion levels. Homozygous knockout mice that lack the related mouse gene exhibit male sterility. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K+. May represent the primary spermatozoan K+ current. In contrast to KCNMA1/SLO1, it is not activated by Ca2+ or Mg2+. Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.
NCBI Summary:This gene encodes a member of the potassium channel family of proteins. The encoded voltage-gated ion channel allows the outward flow of potassium ions during plasma membrane hyperpolarization in sperm. Opening of this channel may be regulated by calcium ion levels. Homozygous knockout mice that lack the related mouse gene exhibit male sterility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Code:A8MYU2
NCBI GenInfo Identifier:157074214
NCBI Gene ID:157855
NCBI Accession:NP_001027006.2
UniProt Related Accession:A8MYU2
Molecular Weight:130 kDa
NCBI Full Name:potassium channel subfamily U member 1
NCBI Synonym Full Names:potassium calcium-activated channel subfamily U member 1
NCBI Official Symbol:KCNU1  
NCBI Official Synonym Symbols:KCa5; Slo3; KCNMC1; KCa5.1; Kcnma3  
NCBI Protein Information:potassium channel subfamily U member 1
UniProt Protein Name:Potassium channel subfamily U member 1
UniProt Synonym Protein Names:Calcium-activated potassium channel subunit alpha-3; Calcium-activated potassium channel, subfamily M subunit alpha-3; KCa5; Slowpoke homolog 3
Protein Family:Potassium channel subfamily
UniProt Gene Name:KCNU1  
Anti-KCNU1 Antibody (CAB14967)Western blot analysis of extracts of rat testis, using KCNU1 antibody (CAB14967) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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