Name: Anti-KCNQ5 Antibody (CAB16134)
Brand: Signal Transduction Antibodies 2
SKU: CAB16134
Availability: OutOfStock

Antibody Name:	Anti-KCNQ5 Antibody
Antibody SKU:	CAB16134
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 624-923 of human KCNQ5 (NP_001153602.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	U-87MG, A-549, Mouse brain, Mouse lung, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 624-923 of human KCNQ5 (NP_001153602.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	KGSA SALA LASF QIPP FECE QTSD YQSP VDSK DLSG SAQN SGCL SRST SANI SRGL QFIL TPNE FSAQ TFYA LSPT MHSQ ATQV PISQ SDGS AVAA TNTI ANQI NTAP KPAA PTTL QIPP PLPA IKHL PRPE TLHP NPAG LQES ISDV TTCL VASK ENVQ VAQS NLTK DRSM RKSF DMGG ETLL SVCP MVPK DLGK SLSV QNLI RSTE ELNI QLSG SESS GSRG SQDF YPKW RESK LFIT DEEV GPEE TETD TFDA APQP AREA AFAS DSLR TGRS RSSQ SICK AGES TDAL SLPH VKLK
Gene ID:	56479
Uniprot:	Q9NR82
Cellular Location:	Membrane, Multi-pass membrane protein
Calculated MW:	46kDa/89kDa/101kDa/102kDa/103kDa/104kDa
Observed MW:	102kDa

Synonyms:

KCNQ5, Kv7.5

Background:

This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	Kv7.5: Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral Chromosomal Location of Human Ortholog: 6q14 Cellular Component: clathrin coat; plasma membrane Molecular Function:delayed rectifier potassium channel activity; inward rectifier potassium channel activity; protein binding; voltage-gated potassium channel activity Biological Process: synaptic transmission
NCBI Summary:	This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
UniProt Code:	Q9NR82
NCBI GenInfo Identifier:	122065285
NCBI Gene ID:	56479
NCBI Accession:	Q9NR82.3
UniProt Secondary Accession:	Q9NR82,Q17RE1, Q5VVP3, Q86W40, Q9NRN0, A6NKT6, A6PVT6 A8MSQ5, B4DS33, B5MC83, B7ZL37, F5GZV0,
UniProt Related Accession:	Q9NR82
Molecular Weight:	102,365 Da
NCBI Full Name:	Potassium voltage-gated channel subfamily KQT member 5
NCBI Synonym Full Names:	potassium voltage-gated channel subfamily Q member 5
NCBI Official Symbol:	KCNQ5
NCBI Official Synonym Symbols:	Kv7.5
NCBI Protein Information:	potassium voltage-gated channel subfamily KQT member 5
UniProt Protein Name:	Potassium voltage-gated channel subfamily KQT member 5
UniProt Synonym Protein Names:	KQT-like 5; Potassium channel subunit alpha KvLQT5; Voltage-gated potassium channel subunit Kv7.5
Protein Family:	Potassium voltage-gated channel subfamily
UniProt Gene Name:	KCNQ5
UniProt Entry Name:	KCNQ5_HUMAN

Western blot analysis of extracts of various cell lines, using KCNQ5 antibody (CAB16134) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

Antibodies

KCNQ5 Antibody (PACO04775)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)