Immunology Antibodies 2
Anti-KCNN4 Antibody (CAB1974)
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- SKU:
- CAB1974
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-KCNN4 Antibody |
| Antibody SKU: | CAB1974 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 288-427 of human KCNN4 (NP_002241.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 288-427 of human KCNN4 (NP_002241.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KLEF NKAE KHVH NFMM DIQY TKEM KESA ARVL QEAW MFYK HTRR KESH AARR HQRK LLAA INAF RQVR LKHR KLRE QVNS MVDI SKMH MILY DLQQ NLSS SHRA LEKQ IDTL AGKL DALT ELLS TALG PRQL PEPS QQSK |
| Gene ID: | 3783 |
| Uniprot: | O15554 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 47kDa |
| Observed MW: | 53kDa |
| Synonyms: | KCNN4, DHS2, IK, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4 |
| Background: | The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. |
| UniProt Protein Function: | KCNN4: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily. |
| UniProt Protein Details: | Protein type:Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: apical plasma membrane; basolateral plasma membrane; cell soma; lipid raft; plasma membrane; voltage-gated potassium channel complex Molecular Function:calcium-activated potassium channel activity; calmodulin binding; Intermediate conductance calcium-activated potassium channel activity; protein binding; protein phosphatase binding; small conductance calcium-activated potassium channel activity Biological Process: calcium ion transport; cell volume homeostasis; defense response; immune system process; phospholipid translocation; positive regulation of protein secretion; positive regulation of T cell receptor signaling pathway; potassium ion transport; saliva secretion; stabilization of membrane potential; synaptic transmission |
| NCBI Summary: | The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15554 |
| NCBI GenInfo Identifier: | 17366160 |
| NCBI Gene ID: | 3783 |
| NCBI Accession: | O15554.1 |
| UniProt Secondary Accession: | O15554,Q53XR4, |
| UniProt Related Accession: | O15554 |
| Molecular Weight: | 47,696 Da |
| NCBI Full Name: | Intermediate conductance calcium-activated potassium channel protein 4 |
| NCBI Synonym Full Names: | potassium calcium-activated channel subfamily N member 4 |
| NCBI Official Symbol: | KCNN4 |
| NCBI Official Synonym Symbols: | IK; IK1; SK4; DHS2; KCA4; hSK4; IKCA1; hKCa4; KCa3.1; hIKCa1 |
| NCBI Protein Information: | intermediate conductance calcium-activated potassium channel protein 4 |
| UniProt Protein Name: | Intermediate conductance calcium-activated potassium channel protein 4 |
| UniProt Synonym Protein Names: | IKCa1; IK1; KCa3.1; KCa4; Putative Gardos channel |
| Protein Family: | Intermediate conductance calcium-activated potassium channel protein |
| UniProt Gene Name: | KCNN4 |
| UniProt Entry Name: | KCNN4_HUMAN |
 | Western blot analysis of extracts of HepG2 cells, using KCNN4 antibody (CAB1974) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 1s. |
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