Antibody Name:	Anti-KCNK9 Antibody
Antibody SKU:	CAB8609
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNK9 (NP_001269463.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	293T, Mouse kidney, Rat kidney

Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNK9 (NP_001269463.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MKRQ NVRT LSLI VCTF TYLL VGAA VFDA LESD HEMR EEEK LKAE EIRI KGKY NISS EDYR QLEL VILQ SEPH RAGV QWKF AGSF YFAI TVIT TIGY GHAA
Gene ID:	51305
Uniprot:	Q9NPC2
Cellular Location:	Cell membrane, Multi-pass membrane protein
Calculated MW:	42kDa
Observed MW:	42kDa/53kDa

Synonyms:

KCNK9, K2p9.1, KT3.2, TASK-3, TASK3

Background:

This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	KCNK9: pH-dependent, voltage-insensitive, background potassium channel protein. Mainly found in the cerebellum. Also found in adrenal gland, kidney and lung. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: integral to plasma membrane; plasma membrane; synaptic vesicle Molecular Function:potassium ion leak channel activity; protein heterodimerization activity; protein homodimerization activity; voltage-gated potassium channel activity Biological Process: potassium ion transport; stabilization of membrane potential; synaptic transmission Disease: Birk-barel Mental Retardation Dysmorphism Syndrome
NCBI Summary:	This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Code:	Q9NPC2
NCBI GenInfo Identifier:	13431426
NCBI Gene ID:	51305
NCBI Accession:	Q9NPC2.1
UniProt Secondary Accession:	Q9NPC2,Q2M290, Q540F2,
UniProt Related Accession:	Q9NPC2
Molecular Weight:
NCBI Full Name:	Potassium channel subfamily K member 9
NCBI Synonym Full Names:	potassium two pore domain channel subfamily K member 9
NCBI Official Symbol:	KCNK9
NCBI Official Synonym Symbols:	KT3.2; TASK3; K2p9.1; TASK-3
NCBI Protein Information:	potassium channel subfamily K member 9
UniProt Protein Name:	Potassium channel subfamily K member 9
UniProt Synonym Protein Names:	Acid-sensitive potassium channel protein TASK-3; TWIK-related acid-sensitive K(+) channel 3; Two pore potassium channel KT3.2; Two pore K(+) channel KT3.2
Protein Family:	Potassium channel subfamily
UniProt Gene Name:	KCNK9
UniProt Entry Name:	KCNK9_HUMAN

	Western blot analysis of extracts of various cell lines, using KCNK9 antibody (CAB8609) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 15s.
	Immunohistochemistry of paraffin-embedded human liver damage using KCNK9 antibody (CAB8609) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human prostate using KCNK9 antibody (CAB8609) at dilution of 1:100 (40x lens).