Signal Transduction Antibodies 2
Anti-KCNK6 Antibody (CAB16087)
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- SKU:
- CAB16087
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-KCNK6 Antibody |
| Antibody SKU: | CAB16087 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 254-313 of human KCNK6 (NP_004814.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BxPC-3, HT-29, K-562, A-549, 293T, Mouse pancreas, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 254-313 of human KCNK6 (NP_004814.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QTFR HVSD LHGL TELI LLPP PCPA SFNA DEDD RVDI LGPQ PESH QQLS ASSH TDYA SIPR |
| Gene ID: | 9424 |
| Uniprot: | Q9Y257 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 19kDa/33kDa |
| Observed MW: | 36kDa |
| Synonyms: | KCNK6, K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2 |
| Background: | This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. |
| UniProt Protein Function: | KCNK6: Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: plasma membrane; voltage-gated potassium channel complex Molecular Function:inward rectifier potassium channel activity; potassium channel activity; potassium ion leak channel activity Biological Process: potassium ion transport; stabilization of membrane potential |
| NCBI Summary: | This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y257 |
| NCBI GenInfo Identifier: | 13124108 |
| NCBI Gene ID: | 9424 |
| NCBI Accession: | Q9Y257.1 |
| UniProt Secondary Accession: | Q9Y257,Q9HB47, |
| UniProt Related Accession: | Q9Y257 |
| Molecular Weight: | 19,903 Da |
| NCBI Full Name: | Potassium channel subfamily K member 6 |
| NCBI Synonym Full Names: | potassium two pore domain channel subfamily K member 6 |
| NCBI Official Symbol: | KCNK6 |
| NCBI Official Synonym Symbols: | TOSS; KCNK8; TWIK2; K2p6.1; TWIK-2 |
| NCBI Protein Information: | potassium channel subfamily K member 6 |
| UniProt Protein Name: | Potassium channel subfamily K member 6 |
| UniProt Synonym Protein Names: | Inward rectifying potassium channel protein TWIK-2; TWIK-originated similarity sequence |
| Protein Family: | Potassium channel subfamily |
| UniProt Gene Name: | KCNK6 |
| UniProt Entry Name: | KCNK6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KCNK6 antibody (CAB16087) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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