Signal Transduction Antibodies 2

Anti-KCNK6 Antibody (CAB16087)

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SKU:
CAB16087
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-KCNK6 Antibody
Antibody SKU:CAB16087
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 254-313 of human KCNK6 (NP_004814.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:BxPC-3, HT-29, K-562, A-549, 293T, Mouse pancreas, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 254-313 of human KCNK6 (NP_004814.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QTFR HVSD LHGL TELI LLPP PCPA SFNA DEDD RVDI LGPQ PESH QQLS ASSH TDYA SIPR
Gene ID:9424
Uniprot:Q9Y257
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:19kDa/33kDa
Observed MW:36kDa
Synonyms:KCNK6, K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2
Background:This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.
UniProt Protein Function:KCNK6: Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: plasma membrane; voltage-gated potassium channel complex

Molecular Function:inward rectifier potassium channel activity; potassium channel activity; potassium ion leak channel activity

Biological Process: potassium ion transport; stabilization of membrane potential

NCBI Summary:This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y257
NCBI GenInfo Identifier:13124108
NCBI Gene ID:9424
NCBI Accession:Q9Y257.1
UniProt Secondary Accession:Q9Y257,Q9HB47,
UniProt Related Accession:Q9Y257
Molecular Weight:19,903 Da
NCBI Full Name:Potassium channel subfamily K member 6
NCBI Synonym Full Names:potassium two pore domain channel subfamily K member 6
NCBI Official Symbol:KCNK6  
NCBI Official Synonym Symbols:TOSS; KCNK8; TWIK2; K2p6.1; TWIK-2  
NCBI Protein Information:potassium channel subfamily K member 6
UniProt Protein Name:Potassium channel subfamily K member 6
UniProt Synonym Protein Names:Inward rectifying potassium channel protein TWIK-2; TWIK-originated similarity sequence
Protein Family:Potassium channel subfamily
UniProt Gene Name:KCNK6  
UniProt Entry Name:KCNK6_HUMAN
Anti-KCNK6 Antibody (CAB16087)Western blot analysis of extracts of various cell lines, using KCNK6 antibody (CAB16087) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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