Signal Transduction Antibodies 1
Anti-KCNK1 Antibody (CAB12835)
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- SKU:
- CAB12835
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-KCNK1 Antibody |
| Antibody SKU: | CAB12835 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 267-336 of human KCNK1 (NP_002236.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, A-549, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 267-336 of human KCNK1 (NP_002236.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FCEL HELK KFRK MFYV KKDK DEDQ VHII EHDQ LSFS SITD QAAG MKED QKQN EPFV ATQS SACV DGPA NH |
| Gene ID: | 3775 |
| Uniprot: | O00180 |
| Cellular Location: | Apical cell membrane, Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Multi-pass membrane protein, Perikaryon, Recycling endosome, dendrite, synapse |
| Calculated MW: | 38kDa |
| Observed MW: | 38kDa |
| Synonyms: | KCNK1, DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1 |
| Background: | This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. |
| UniProt Protein Function: | KCNK1: Weakly inward rectifying potassium channel. Homodimer (Potential). Widely expressed with high levels in heart and brain and lower levels in placenta, lung, liver and kidney. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1q42.2 Cellular Component: integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; plasma membrane; voltage-gated potassium channel complex Molecular Function:inward rectifier potassium channel activity; potassium channel activity; potassium ion leak channel activity; sodium channel activity; voltage-gated potassium channel activity Biological Process: potassium ion transport; regulation of resting membrane potential |
| NCBI Summary: | This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00180 |
| NCBI GenInfo Identifier: | 13124036 |
| NCBI Gene ID: | 3775 |
| NCBI Accession: | O00180.1 |
| UniProt Secondary Accession: | O00180,Q13307, Q5T5E8, |
| UniProt Related Accession: | O00180 |
| Molecular Weight: | |
| NCBI Full Name: | Potassium channel subfamily K member 1 |
| NCBI Synonym Full Names: | potassium two pore domain channel subfamily K member 1 |
| NCBI Official Symbol: | KCNK1 |
| NCBI Official Synonym Symbols: | DPK; HOHO; K2P1; KCNO1; TWIK1; K2p1.1; TWIK-1 |
| NCBI Protein Information: | potassium channel subfamily K member 1 |
| UniProt Protein Name: | Potassium channel subfamily K member 1 |
| UniProt Synonym Protein Names: | Inward rectifying potassium channel protein TWIK-1 |
| Protein Family: | Potassium channel subfamily |
| UniProt Gene Name: | KCNK1 |
 | Western blot analysis of extracts of various cell lines, using KCNK1 antibody (CAB12835) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat heart using KCNK1 antibody (CAB12835) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using KCNK1 antibody (CAB12835) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using KCNK1 antibody (CAB12835) at dilution of 1:100 (40x lens). |
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