Signal Transduction Antibodies 3

Anti-KCNJ6 Antibody (CAB9935)

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SKU:
CAB9935
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-KCNJ6 Antibody
Antibody SKU:CAB9935
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human KCNJ6 (NP_002231.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:NIH/3T3, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human KCNJ6 (NP_002231.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAKL TESM TNVL EGDS MDQD VESP VAIH QPKL PKQA RDDL PRHI SRDR TKRK IQRY VRKD GKCN VHHG NVRE TYRY LTDI
Gene ID:3763
Uniprot:P48051
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:48kDa
Observed MW:48kDa
Synonyms:KCNJ6, BIR1, GIRK-2, GIRK2, KATP-2, KATP2, KCNJ7, KIR3.2, KPLBS, hiGIRK2
Background:This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability.
UniProt Protein Function:This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
NCBI Summary:This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015]
UniProt Code:P48051
NCBI GenInfo Identifier:4504843
NCBI Gene ID:3763
NCBI Accession:NP_002231.1
UniProt Secondary Accession:P48051,Q3MJ74, Q53WW6,
UniProt Related Accession:P48051
Molecular Weight:46
NCBI Full Name:G protein-activated inward rectifier potassium channel 2
NCBI Synonym Full Names:potassium voltage-gated channel subfamily J member 6
NCBI Official Symbol:KCNJ6  
NCBI Official Synonym Symbols:BIR1; GIRK2; KATP2; KCNJ7; KPLBS; GIRK-2; KATP-2; KIR3.2; hiGIRK2  
NCBI Protein Information:G protein-activated inward rectifier potassium channel 2
UniProt Protein Name:G protein-activated inward rectifier potassium channel 2
UniProt Synonym Protein Names:BIR1; Inward rectifier K(+) channel Kir3.2; KATP-2; Potassium channel, inwardly rectifying subfamily J member 6
UniProt Gene Name:KCNJ6  
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