Antibody Name:	Anti-KCNJ4 Antibody
Antibody SKU:	CAB8434
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 316-445 of human KCNJ4 (NP_690607.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse, Rat
Positive Samples:	Mouse thymus, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 316-445 of human KCNJ4 (NP_690607.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	HRFE PVVF EEKS HYKV DYSR FHKT YEVA GTPC CSAR ELQE SKIT VLPA PPPP PSAF CYEN ELAL MSQE EEEM EEEA AAAA AVAA GLGL EAGS KEEA GIIR MLEF GSHL DLER MQAS LPLD NISY RRES AI
Gene ID:	3761
Uniprot:	P48050
Cellular Location:	Cell junction, Cell membrane, Cytoplasmic vesicle membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:	49kDa
Observed MW:	60kDa

Synonyms:

KCNJ4, HIR, HIRK2, HRK1, IRK-3, IRK3, Kir2.3

Background:

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene.

UniProt Protein Function:	HIR: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: basolateral plasma membrane; plasma membrane; voltage-gated potassium channel complex Molecular Function:G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; PDZ domain binding; protein binding Biological Process: potassium ion import; potassium ion transport
NCBI Summary:	Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	P48050
NCBI GenInfo Identifier:	1352483
NCBI Gene ID:	3761
NCBI Accession:	P48050.1
UniProt Secondary Accession:	P48050,Q14D44,
UniProt Related Accession:	P48050
Molecular Weight:	49,500 Da
NCBI Full Name:	Inward rectifier potassium channel 4
NCBI Synonym Full Names:	potassium voltage-gated channel subfamily J member 4
NCBI Official Symbol:	KCNJ4
NCBI Official Synonym Symbols:	HIR; HRK1; IRK3; HIRK2; IRK-3; Kir2.3
NCBI Protein Information:	inward rectifier potassium channel 4
UniProt Protein Name:	Inward rectifier potassium channel 4
UniProt Synonym Protein Names:	HIRK2; HRK1; Hippocampal inward rectifier; HIR; Inward rectifier K(+) channel Kir2.3; IRK-3; Potassium channel, inwardly rectifying subfamily J member 4
Protein Family:	Inward rectifier potassium channel
UniProt Gene Name:	KCNJ4
UniProt Entry Name:	KCNJ4_HUMAN