Signal Transduction Antibodies 1

Anti-KCNJ2 Antibody (CAB10708)

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SKU:
CAB10708
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-KCNJ2 Antibody
Antibody SKU:CAB10708
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ2 (NP_000882.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ2 (NP_000882.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KDGH CNVQ FINV GEKG QRYL ADIF TTCV DIRW RWML VIFC LAFV LSWL FFGC VFWL IALL HGDL DASK EGKA CVSE VNSF TAAF LFSI ETQT TIGY GFRC V
Gene ID:3759
Uniprot:P63252
Cellular Location:Lipid-anchor, Membrane, Multi-pass membrane protein
Calculated MW:48kDa
Observed MW:Refer to Figures
Synonyms:KCNJ2, ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3
Background:Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features.
UniProt Protein Function:KCNJ2: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium. Defects in KCNJ2 are the cause of long QT syndrome type 7 (LQT7); also called Andersen syndrome or Andersen cardiodysrhythmic periodic paralysis. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. LQT7 manifests itself as a clinical triad consisting of potassium-sensitive periodic paralysis, ventricular ectopy and dysmorphic features. Defects in KCNJ2 are the cause of short QT syndrome type 3 (SQT3). Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death. SQT3 has a unique ECG phenotype characterized by asymmetrical T waves. Defects in KCNJ2 are the cause of familial atrial fibrillation type 9 (ATFB9). ATFB9 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
UniProt Protein Details:

Protein type:Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q24.3

Cellular Component: integral to plasma membrane; intrinsic to membrane; plasma membrane; voltage-gated potassium channel complex

Molecular Function:G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; phosphatidylinositol-4,5-bisphosphate binding

Biological Process: cellular potassium ion homeostasis; potassium ion import; potassium ion transport; protein homotetramerization; regulation of resting membrane potential; regulation of skeletal muscle contraction via membrane action potential

Disease: Andersen Cardiodysrhythmic Periodic Paralysis; Atrial Fibrillation, Familial, 9; Short Qt Syndrome 3

NCBI Summary:Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008]
UniProt Code:P63252
NCBI GenInfo Identifier:54037433
NCBI Gene ID:3759
NCBI Accession:P63252.1
UniProt Secondary Accession:P63252,O15110, P48049,
UniProt Related Accession:P63252
Molecular Weight:48kDa
NCBI Full Name:Inward rectifier potassium channel 2
NCBI Synonym Full Names:potassium voltage-gated channel subfamily J member 2
NCBI Official Symbol:KCNJ2  
NCBI Official Synonym Symbols:IRK1; LQT7; SQT3; ATFB9; HHIRK1; KIR2.1; HHBIRK1  
NCBI Protein Information:inward rectifier potassium channel 2
UniProt Protein Name:Inward rectifier potassium channel 2
UniProt Synonym Protein Names:Cardiac inward rectifier potassium channel; Inward rectifier K(+) channel Kir2.1; IRK-1; hIRK1; Potassium channel, inwardly rectifying subfamily J member 2
Protein Family:Inward rectifier potassium channel
UniProt Gene Name:KCNJ2  
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