Signal Transduction Antibodies 3

Anti-KCNJ10 Antibody (CAB9826)

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SKU:
CAB9826
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-KCNJ10 Antibody
Antibody SKU:CAB9826
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ10 (NP_002232.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, MCF7, Mouse brain, Rat brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ10 (NP_002232.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LYLK DLWT TFID MQWR YKLL LFSA TFAG TWFL FGVV WYLV AVAH GDLL ELDP PANH TPCV VQVH TLTG AFLF SLES QTTI GYGF RYIS EECP LAIV LLIA Q
Gene ID:3766
Uniprot:P78508
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:42kDa
Observed MW:42kDa
Synonyms:KCNJ10, BIRK-10, KCNJ13-PEN, KIR1.2, KIR4.1, SESAME
Background:This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes.
UniProt Protein Function:Kir4.1: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Defects in KCNJ10 are the cause of seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SESAMES). A complex disorder characterized by generalized seizures with onset in infancy, delayed psychomotor development, ataxia, sensorineural hearing loss, hypokalemia, metabolic alkalosis, and hypomagnesemia. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass; Channel, potassium

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: microvillus; integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane

Molecular Function:identical protein binding; protein binding; ATP-activated inward rectifier potassium channel activity; ATP binding; receptor binding

Biological Process: regulation of long-term neuronal synaptic plasticity; myelination in the central nervous system; response to glucocorticoid stimulus; membrane hyperpolarization; response to blue light; glutamate uptake during transmission of nerve impulse; response to mineralocorticoid stimulus; adult walking behavior; protein homotetramerization; synaptic transmission; visual perception; potassium ion import; optic nerve development; regulation of resting membrane potential; regulation of sensory perception of pain; inflammatory response; potassium ion homeostasis; potassium ion transport

Disease: Pendred Syndrome; Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance; Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct

NCBI Summary:This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]
UniProt Code:P78508
NCBI GenInfo Identifier:2493605
NCBI Gene ID:3766
NCBI Accession:P78508.1
UniProt Secondary Accession:P78508,Q5VUT9, Q8N4I7, Q92808, A3KME7,
UniProt Related Accession:P78508
Molecular Weight:42,508 Da
NCBI Full Name:ATP-sensitive inward rectifier potassium channel 10
NCBI Synonym Full Names:potassium inwardly-rectifying channel, subfamily J, member 10
NCBI Official Symbol:KCNJ10  
NCBI Official Synonym Symbols:KIR1.2; KIR4.1; SESAME; BIRK-10; KCNJ13-PEN  
NCBI Protein Information:ATP-sensitive inward rectifier potassium channel 10; inward rectifier K+ channel KIR1.2; inward rectifier K(+) channel Kir1.2; ATP-dependent inwardly rectifying potassium channel Kir4.1; potassium channel, inwardly rectifying subfamily J member 10; glial ATP-dependent inwardly rectifying potassium channel KIR4.1
UniProt Protein Name:ATP-sensitive inward rectifier potassium channel 10
UniProt Synonym Protein Names:ATP-dependent inwardly rectifying potassium channel Kir4.1; Inward rectifier K(+) channel Kir1.2; Potassium channel, inwardly rectifying subfamily J member 10
Protein Family:ATP-sensitive inward rectifier potassium channel
UniProt Gene Name:KCNJ10  
UniProt Entry Name:KCJ10_HUMAN
Anti-KCNJ10 Polyclonal Antibody (CAB9826)Western blot analysis of extracts of various cell lines, using KCNJ10 Antibody (CAB9826) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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