Cell Death Antibodies 1

Anti-KCNIP3 Antibody (CAB13711)

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SKU:
CAB13711
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-KCNIP3 Antibody
Antibody SKU:CAB13711
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNIP3 (NP_038462.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat heart
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNIP3 (NP_038462.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MQPA KEVT KASD GSLL GDLG HTPL SKKE GIKW QRPR LSRQ ALMR CCLV KWIL SSTA PQGS DSSD SELE LSTV RHQP EGLD QLQA QTKF TKKE LQSL YRGF
Gene ID:30818
Uniprot:Q9Y2W7
Cellular Location:Cell membrane, Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Lipid-anchor, Nucleus
Calculated MW:26kDa/29kDa
Observed MW:29kDa
Synonyms:KCNIP3, CSEN, DREAM, KCHIP3
Background:This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.
UniProt Protein Function:calsenilin: a small calcium-binding protein. Member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Modulates K4 voltage-gated potassium channels. May regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Also functions as a calcium-regulated transcriptional repressor, and to interact with presenilins. May play a role in the regulation of PSEN2 proteolytic processing.
UniProt Protein Details:

Protein type:Transcription factor; Calcium-binding

Chromosomal Location of Human Ortholog: 2q21.1

Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; endoplasmic reticulum; dendrite; nerve terminal; nucleus; cytosol

Molecular Function:protein C-terminus binding; potassium channel regulator activity; potassium channel activity; DNA binding; sequence-specific DNA binding; voltage-gated ion channel activity; calcium ion binding; calcium-dependent protein binding; transcription corepressor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; intracellular protein transport; behavioral response to pain; transcription, DNA-dependent; apoptosis; regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; sensory perception of pain; signal transduction

NCBI Summary:This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y2W7
NCBI GenInfo Identifier:13431428
NCBI Gene ID:30818
NCBI Accession:Q9Y2W7.1
UniProt Secondary Accession:Q9Y2W7,Q3YAC3, Q3YAC4, Q53TJ5, Q96T40, Q9UJ84, Q9UJ85 H7BY46,
UniProt Related Accession:Q9Y2W7
Molecular Weight:26,335 Da
NCBI Full Name:Calsenilin
NCBI Synonym Full Names:Kv channel interacting protein 3, calsenilin
NCBI Official Symbol:KCNIP3  
NCBI Official Synonym Symbols:CSEN; DREAM; KCHIP3  
NCBI Protein Information:calsenilin; DRE-antagonist modulator; kv channel-interacting protein 3; potassium channel interacting protein 3; A-type potassium channel modulatory protein 3; calsenilin, presenilin-binding protein, EF hand transcription factor
UniProt Protein Name:Calsenilin
UniProt Synonym Protein Names:A-type potassium channel modulatory protein 3; DRE-antagonist modulator; DREAM; Kv channel-interacting protein 3; KChIP3
Protein Family:Calsenilin
UniProt Gene Name:KCNIP3  
UniProt Entry Name:CSEN_HUMAN
Anti-KCNIP3 Antibody (CAB13711)Western blot analysis of extracts of rat heart, using KCNIP3 antibody (CAB13711) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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