Metabolism Antibodies 2

Anti-KCNIP2 Antibody (CAB7100)

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SKU:
CAB7100
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-KCNIP2 Antibody
Antibody SKU:CAB7100
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human KCNIP2 (NP_775284.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Mouse heart, Mouse pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human KCNIP2 (NP_775284.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MRGQ GRKE SLSD SRDL DGSY DQLT GHPP GPTK KALK QRFL KLLP CCGP QALP SVSE NSVD DEFE LSTV CHRP EGLE QLQE QTKF TRKE LQ
Gene ID:30819
Uniprot:Q9NS61
Cellular Location:Cell membrane, Lipid-anchor, Lipid-anchor
Calculated MW:20kDa/21kDa/25kDa/26kDa/28kDa/30kDa/32kDa
Observed MW:24kDa
Synonyms:KCNIP2, KCHIP2
Background:This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene.
UniProt Protein Function:KCNIP2: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Belongs to the recoverin family. 9 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 10q24Cellular Component: voltage-gated potassium channel complex; cytoplasmMolecular Function: identical protein binding; protein binding; potassium channel regulator activity; protein N-terminus binding; calcium ion binding; ER retention sequence binding; A-type (transient outward) potassium channel activityBiological Process: synaptic transmission; muscle contraction; clustering of voltage-gated potassium channels; detection of calcium ion; signal transduction; regulation of heart contraction; potassium ion transport
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NS61
NCBI GenInfo Identifier:338817979
NCBI Gene ID:30819
NCBI Accession:Q9NS61.3
UniProt Secondary Accession:Q9NS61
UniProt Related Accession:Q9NS61
Molecular Weight:24kDa
NCBI Full Name:Kv channel-interacting protein 2
NCBI Synonym Full Names:potassium voltage-gated channel interacting protein 2
NCBI Official Symbol:KCNIP2  
NCBI Official Synonym Symbols:KCHIP2  
NCBI Protein Information:Kv channel-interacting protein 2
UniProt Protein Name:Kv channel-interacting protein 2
UniProt Synonym Protein Names:A-type potassium channel modulatory protein 2; Cardiac voltage-gated potassium channel modulatory subunit; Potassium channel-interacting protein 2
Protein Family:Kv channel-interacting protein
UniProt Gene Name:KCNIP2  
UniProt Entry Name:KCIP2_HUMAN
Anti-KCNIP2 Antibody (CAB7100)Western blot analysis of extracts of various cell lines, using KCNIP2 antibody (CAB7100) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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