Signal Transduction Antibodies 2

Anti-KCNIP1 Antibody (CAB4684)

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SKU:
CAB4684
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
KCNIP1
Synonyms:
KCHIP1
Synonyms:
VABP

Description

Product Name:KCNIP1 Rabbit pAb
Product Code:CAB4684
Size:20uL, 50uL, 100uL
Synonyms:KCNIP1, KCHIP1, VABP
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-216 of human KCNIP1 (NP_055407.1).
Applications:WB
Recommended Dilutions:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:BxPC-3, Mouse brain, Mouse kidney, Mouse lung, Rat eye
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-216 of human KCNIP1 (NP_055407.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGAV MGTF SSLQ TKQR RPSK DKIE DELE MTMV CHRP EGLE QLEA QTNF TKRE LQVL YRGF KNEC PSGV VNED TFKQ IYAQ FFPH GDAS TYAH YLFN AFDT TQTG SVKF EDFV TALS ILLR GTVH EKLR WTFN LYDI NKDG YINK EEMM DIVK AIYD MMGK YTYP VLKE DTPR QHVD VFFQ KMDK NKDG IVTL DEFL ESCQ EDDN IMRS LQLF QNVM
Gene ID:30820
Uniprot:Q9NZI2
Cellular Location:Cell membrane, Cell projection, Cytoplasm, Peripheral membrane protein, dendrite
Calculated MW:21kDa/22kDa/26kDa/27kDa
Observed MW:27-37kDa
UniProt Protein Function:KCNIP1: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface. Belongs to the recoverin family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: voltage-gated potassium channel complex; extrinsic to internal side of plasma membrane; cell soma; cytoplasm; dendrite

Molecular Function:protein binding; potassium channel regulator activity; potassium channel activity; protein heterodimerization activity; protein N-terminus binding; voltage-gated ion channel activity; calcium ion binding

Biological Process: positive regulation of action potential

NCBI Summary:This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
UniProt Code:Q9NZI2
NCBI GenInfo Identifier:73621122
NCBI Gene ID:30820
NCBI Accession:Q9NZI2.2
UniProt Secondary Accession:Q9NZI2,Q3YAD0, Q3YAD1, Q3YAD2, Q3YAD3, Q5U822, B7Z7B4
UniProt Related Accession:Q9NZI2
Molecular Weight:227
NCBI Full Name:Kv channel-interacting protein 1
NCBI Synonym Full Names:Kv channel interacting protein 1
NCBI Official Symbol:KCNIP1  
NCBI Official Synonym Symbols:VABP; KCHIP1  
NCBI Protein Information:Kv channel-interacting protein 1; vesicle APC-binding protein; potassium channel interacting protein 1; A-type potassium channel modulatory protein 1
UniProt Protein Name:Kv channel-interacting protein 1
UniProt Synonym Protein Names:A-type potassium channel modulatory protein 1; Potassium channel-interacting protein 1; Vesicle APC-binding protein
UniProt Gene Name:KCNIP1  
UniProt Entry Name:KCIP1_HUMAN
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