Signal Transduction Antibodies 2
Anti-KCNIP1 Antibody (CAB4684)
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- SKU:
- CAB4684
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- KCNIP1
- Synonyms:
- KCHIP1
- Synonyms:
- VABP
Description
| Product Name: | KCNIP1 Rabbit pAb |
| Product Code: | CAB4684 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | KCNIP1, KCHIP1, VABP |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-216 of human KCNIP1 (NP_055407.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BxPC-3, Mouse brain, Mouse kidney, Mouse lung, Rat eye |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-216 of human KCNIP1 (NP_055407.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGAV MGTF SSLQ TKQR RPSK DKIE DELE MTMV CHRP EGLE QLEA QTNF TKRE LQVL YRGF KNEC PSGV VNED TFKQ IYAQ FFPH GDAS TYAH YLFN AFDT TQTG SVKF EDFV TALS ILLR GTVH EKLR WTFN LYDI NKDG YINK EEMM DIVK AIYD MMGK YTYP VLKE DTPR QHVD VFFQ KMDK NKDG IVTL DEFL ESCQ EDDN IMRS LQLF QNVM |
| Gene ID: | 30820 |
| Uniprot: | Q9NZI2 |
| Cellular Location: | Cell membrane, Cell projection, Cytoplasm, Peripheral membrane protein, dendrite |
| Calculated MW: | 21kDa/22kDa/26kDa/27kDa |
| Observed MW: | 27-37kDa |
| UniProt Protein Function: | KCNIP1: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface. Belongs to the recoverin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5q35.1 Cellular Component: voltage-gated potassium channel complex; extrinsic to internal side of plasma membrane; cell soma; cytoplasm; dendrite Molecular Function:protein binding; potassium channel regulator activity; potassium channel activity; protein heterodimerization activity; protein N-terminus binding; voltage-gated ion channel activity; calcium ion binding Biological Process: positive regulation of action potential |
| NCBI Summary: | This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013] |
| UniProt Code: | Q9NZI2 |
| NCBI GenInfo Identifier: | 73621122 |
| NCBI Gene ID: | 30820 |
| NCBI Accession: | Q9NZI2.2 |
| UniProt Secondary Accession: | Q9NZI2,Q3YAD0, Q3YAD1, Q3YAD2, Q3YAD3, Q5U822, B7Z7B4 |
| UniProt Related Accession: | Q9NZI2 |
| Molecular Weight: | 227 |
| NCBI Full Name: | Kv channel-interacting protein 1 |
| NCBI Synonym Full Names: | Kv channel interacting protein 1 |
| NCBI Official Symbol: | KCNIP1 |
| NCBI Official Synonym Symbols: | VABP; KCHIP1 |
| NCBI Protein Information: | Kv channel-interacting protein 1; vesicle APC-binding protein; potassium channel interacting protein 1; A-type potassium channel modulatory protein 1 |
| UniProt Protein Name: | Kv channel-interacting protein 1 |
| UniProt Synonym Protein Names: | A-type potassium channel modulatory protein 1; Potassium channel-interacting protein 1; Vesicle APC-binding protein |
| UniProt Gene Name: | KCNIP1 |
| UniProt Entry Name: | KCIP1_HUMAN |
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