Signal Transduction Antibodies 2

Anti-KCNH6 Antibody (CAB15522)

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SKU:
CAB15522
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-KCNH6 Antibody
Antibody SKU:CAB15522
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 70-220 of human KCNH6 (NP_110406.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human
Positive Samples:293T, HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 70-220 of human KCNH6 (NP_110406.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TGPN TPSS AVSR LAQA LLGA EECK VDIL YYRK DASS FRCL VDVV PVKN EDGA VIMF ILNF EDLA QLLA KCSS RSLS QRLL SQSF LGSE GSHG RPGG PGPG TGRG KYRT ISQI PQFT LNFV EFNL EKHR SSST TEIE IIAP HKVV ERTQ NVT
Gene ID:81033
Uniprot:Q9H252
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:56kDa/100kDa/109kDa
Observed MW:110kDa
Synonyms:KCNH6, ERG-2, ERG2, HERG2, Kv11.2, hERG-2
Background:Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms.
UniProt Protein Function:Kv11.2: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.2/KCNH6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:voltage-gated potassium channel activity; signal transducer activity

Biological Process: synaptic transmission; regulation of membrane potential; signal transduction

NCBI Summary:Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
UniProt Code:Q9H252
NCBI GenInfo Identifier:524550850
NCBI Gene ID:81033
NCBI Accession:NP_001265848.1
UniProt Secondary Accession:Q9H252,Q9BRD7,
UniProt Related Accession:Q9H252
Molecular Weight:56,298 Da
NCBI Full Name:potassium voltage-gated channel subfamily H member 6 isoform 3
NCBI Synonym Full Names:potassium channel, voltage gated eag related subfamily H, member 6
NCBI Official Symbol:KCNH6  
NCBI Official Synonym Symbols:ERG2; ERG-2; HERG2; Kv11.2; hERG-2  
NCBI Protein Information:potassium voltage-gated channel subfamily H member 6
UniProt Protein Name:Potassium voltage-gated channel subfamily H member 6
UniProt Synonym Protein Names:Ether-a-go-go-related gene potassium channel 2; ERG-2; Eag-related protein 2; Ether-a-go-go-related protein 2; hERG-2; hERG2; Voltage-gated potassium channel subunit Kv11.2
Protein Family:Potassium voltage-gated channel subfamily
UniProt Gene Name:KCNH6  
UniProt Entry Name:KCNH6_HUMAN
Anti-KCNH6 Antibody (CAB15522)Western blot analysis of extracts of various cell lines, using KCNH6 Rabbit pAb (CAB15522) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s.
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