Signal Transduction Antibodies 1

Anti-KCNE4 Antibody (CAB12184)

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SKU:
CAB12184
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-KCNE4 Antibody
Antibody SKU:CAB12184
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 108-221 of human KCNE4 (NP_542402.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human
Positive Samples:293T, LO2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 108-221 of human KCNE4 (NP_542402.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YMKS KRRE KKSS LLLL YKDE ERLW GEAM KPLP VVSG LRSV QVPL MLNM LQES VAPA LSCT LCSM EGDS VSSE SSSP DVHL TIQE EGAD DELE ETSE TPLN ESSE GSSE NIHQ NS
Gene ID:23704
Uniprot:Q8WWG9
Cellular Location:Membrane, Single-pass membrane protein
Calculated MW:23kDa
Observed MW:30kDa
Synonyms:KCNE4, MIRP3
Background:Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus.
UniProt Protein Function:KCNE4: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current. Belongs to the potassium channel KCNE family.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q36.1

Molecular Function:protein binding

NCBI Summary:Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WWG9
NCBI GenInfo Identifier:677286760
NCBI Gene ID:23704
NCBI Accession:Q8WWG9.4
UniProt Secondary Accession:Q8WWG9,Q53SM4, Q96CC4, B7Z275,
UniProt Related Accession:Q8WWG9
Molecular Weight:23,806 Da
NCBI Full Name:Potassium voltage-gated channel subfamily E member 4
NCBI Synonym Full Names:potassium voltage-gated channel subfamily E regulatory subunit 4
NCBI Official Symbol:KCNE4  
NCBI Official Synonym Symbols:MIRP3  
NCBI Protein Information:potassium voltage-gated channel subfamily E member 4
UniProt Protein Name:Potassium voltage-gated channel subfamily E member 4
UniProt Synonym Protein Names:MinK-related peptide 3; Minimum potassium ion channel-related peptide 3; Potassium channel subunit beta MiRP3
Protein Family:Potassium voltage-gated channel subfamily
UniProt Gene Name:KCNE4  
UniProt Entry Name:KCNE4_HUMAN
Anti-KCNE4 Antibody (CAB12184)Western blot analysis of extracts of various cell lines, using KCNE4 antibody (CAB12184) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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