Antibody Name:	Anti-KCND2 Antibody
Antibody SKU:	CAB6203
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 501-630 of human KCND2 (NP_036413.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Rat
Positive Samples:	THP-1, Rat brain, Rat heart

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 501-630 of human KCND2 (NP_036413.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	ESCM EVAT VNRP SSHS PSLS SQQG VTST CCSR RHKK TFRI PNAN VSGS HQGS IQEL STIQ IRCV ERTP LSNS RSSL NAKM EECV KLNC EQPY VTTA IISI PTPP VTTP EGDD RPES PEYS GGNI VRVS AL
Gene ID:	3751
Uniprot:	Q9NZV8
Cellular Location:	Cell junction, Cell membrane, Cell projection, Multi-pass membrane protein, Perikaryon, dendrite, dendritic spine, postsynaptic cell membrane, synapse
Calculated MW:	70kDa
Observed MW:	82kDa

Synonyms:

KCND2, KV4.2, RK5

Background:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.

UniProt Protein Function:	Kv4.2: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
UniProt Protein Details:	Protein type:Membrane protein, integral; Membrane protein, multi-pass; Channel, potassium Chromosomal Location of Human Ortholog: 7q31 Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; integral to plasma membrane; integral to membrane; plasma membrane; dendritic spine; intrinsic to plasma membrane Molecular Function:protein binding; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; metal ion binding; A-type (transient outward) potassium channel activity Biological Process: regulation of action potential; synaptic transmission; protein homooligomerization
NCBI Summary:	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9NZV8
NCBI GenInfo Identifier:	38258257
NCBI Gene ID:	3751
NCBI Accession:	Q9NZV8.2
UniProt Secondary Accession:	Q9NZV8,O95012, O95021, Q2TBD3, Q9UBY7, Q9UN98, Q9UNH9
UniProt Related Accession:	Q9NZV8
Molecular Weight:	630
NCBI Full Name:	Potassium voltage-gated channel subfamily D member 2
NCBI Synonym Full Names:	potassium voltage-gated channel, Shal-related subfamily, member 2
NCBI Official Symbol:	KCND2
NCBI Official Synonym Symbols:	RK5; KV4.2
NCBI Protein Information:	potassium voltage-gated channel subfamily D member 2; voltage-sensitive potassium channel; voltage-gated potassium channel subunit Kv4.2
UniProt Protein Name:	Potassium voltage-gated channel subfamily D member 2
UniProt Synonym Protein Names:	Voltage-gated potassium channel subunit Kv4.2
Protein Family:	Potassium voltage-gated channel subfamily
UniProt Gene Name:	KCND2
UniProt Entry Name:	KCND2_HUMAN

	Western blot analysis of extracts of various cell lines, using KCND2 antibody (CAB6203) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
	Immunohistochemistry of paraffin-embedded human stomach using KCND2 antibody (CAB6203) at dilution of 1:100 (40x lens).