Name: Anti-KCNAB1 Antibody (CAB15334)
Brand: Signal Transduction Antibodies 2
SKU: CAB15334
Availability: OutOfStock

Antibody Name:	Anti-KCNAB1 Antibody
Antibody SKU:	CAB15334
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 282-401 of human KCNAB1 (NP_751891.1).

Application:	WB
Recommended Dilution:	WB 1:200 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	U-251MG, 293T, Mouse brain, Mouse kidney, Mouse heart, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 282-401 of human KCNAB1 (NP_751891.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	CGII SGKY GNGV PESS RASL KCYQ WLKE RIVS EEGR KQQN KLKD LSPI AERL GCTL PQLA VAWC LRNE GVSS VLLG SSTP EQLI ENLG AIQV LPKM TSHV VNEI DNIL RNKP YSKK DYRS
Gene ID:	7881
Uniprot:	Q14722
Cellular Location:	Cell membrane, Cytoplasm, Cytoplasmic side, Membrane, Peripheral membrane protein
Calculated MW:	44kDa/45kDa/46kDa
Observed MW:	45-50kDa

Synonyms:

KCNAB1, AKR6A3, KCNA1B, KV-BETA-1, Kvb1.3, hKvBeta3, hKvb3

Background:

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alpha subunits.

UniProt Protein Function:	Kv-beta1: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1. Belongs to the shaker potassium channel beta subunit family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Channel, potassium Chromosomal Location of Human Ortholog: 3q26.1 Cellular Component: cytosol; extrinsic to internal side of plasma membrane; plasma membrane Molecular Function:aldo-keto reductase activity; potassium channel regulator activity Biological Process: potassium ion transport
NCBI Summary:	Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Apr 2015]
UniProt Code:	Q14722
NCBI GenInfo Identifier:	18202500
NCBI Gene ID:	7881
NCBI Accession:	Q14722.1
UniProt Secondary Accession:	Q14722,Q13031, Q13302, Q16547, Q6PI60, Q99869, A8K9H8 A8KAD4, B3KPZ4,
UniProt Related Accession:	Q14722
Molecular Weight:	45,492 Da
NCBI Full Name:	Voltage-gated potassium channel subunit beta-1
NCBI Synonym Full Names:	potassium voltage-gated channel subfamily A member regulatory beta subunit 1
NCBI Official Symbol:	KCNAB1
NCBI Official Synonym Symbols:	hKvb3; AKR6A3; KCNA1B; Kvb1.3; hKvBeta3; KV-BETA-1
NCBI Protein Information:	voltage-gated potassium channel subunit beta-1
UniProt Protein Name:	Voltage-gated potassium channel subunit beta-1
UniProt Synonym Protein Names:	K(+) channel subunit beta-1; Kv-beta-1
Protein Family:	Voltage-gated potassium channel
UniProt Gene Name:	KCNAB1
UniProt Entry Name:	KCAB1_HUMAN

Western blot analysis of extracts of various cell lines, using KCNAB1 antibody (CAB15334) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

Antibodies

KCNAB1 Antibody (PACO07189)

KCNAB1 Antibody (PACO10045)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)