Signal Transduction Antibodies 2

Anti-KCNA4 Antibody (CAB16390)

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SKU:
CAB16390
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-KCNA4 Antibody
Antibody SKU:CAB16390
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 250-350 of human KCNA4 (NP_002224.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Rat brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 250-350 of human KCNA4 (NP_002224.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DIFT EEVK FYQL GEEA LLKF REDE GFVR EEED RALP ENEF KKQI WLLF EYPE SSSP ARGI AIVS VLVI LISI VIFC LETL PEFR DDRD LVMA LSAG GHGG L
Gene ID:3739
Uniprot:P22459
Cellular Location:Cell membrane, Cell projection, Multi-pass membrane protein, axon
Calculated MW:73kDa
Observed MW:71kDa
Synonyms:KCNA4, HBK4, HK1, HPCN2, HUKII, KCNA4L, KCNA8, KV1.4, PCN2
Background:Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.
UniProt Protein Function:Kv1.4: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
UniProt Protein Details:

Protein type:Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p14

Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; axon; plasma membrane; integral to membrane

Molecular Function:potassium ion binding; voltage-gated potassium channel activity; protein binding; delayed rectifier potassium channel activity

Biological Process: synaptic transmission; potassium ion transport; protein homooligomerization

NCBI Summary:Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011]
UniProt Code:P22459
NCBI GenInfo Identifier:313104127
NCBI Gene ID:3739
NCBI Accession:P22459.2
UniProt Related Accession:P22459
Molecular Weight:73,257 Da
NCBI Full Name:Potassium voltage-gated channel subfamily A member 4
NCBI Synonym Full Names:potassium voltage-gated channel, shaker-related subfamily, member 4
NCBI Official Symbol:KCNA4  
NCBI Official Synonym Symbols:HK1; HBK4; PCN2; HPCN2; HUKII; KCNA8; KV1.4; KCNA4L  
NCBI Protein Information:potassium voltage-gated channel subfamily A member 4; potassium channel 2; type A potassium channel; cardiac potassium channel; voltage-gated K(+) channel HuKII; voltage-gated potassium channel HK1; voltage-gated potassium channel HBK4; rapidly inactivating potassium channel; shaker-related potassium channel Kv1.4; fetal skeletal muscle potassium channel; voltage-gated potassium channel subunit Kv1.4
UniProt Protein Name:Potassium voltage-gated channel subfamily A member 4
UniProt Synonym Protein Names:HPCN2; Voltage-gated K(+) channel HuKII; Voltage-gated potassium channel HBK4; Voltage-gated potassium channel HK1; Voltage-gated potassium channel subunit Kv1.4
Protein Family:Potassium voltage-gated channel subfamily
UniProt Gene Name:KCNA4  
UniProt Entry Name:KCNA4_HUMAN
Anti-KCNA4 Antibody (CAB16390)Western blot analysis of extracts of Rat brain, using KCNA4 Rabbit pAb (CAB16390) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s.
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