Name: Anti-KCNA10 Antibody (CAB15681)
Brand: Signal Transduction Antibodies 2
SKU: CAB15681
Availability: OutOfStock

Antibody Name:	Anti-KCNA10 Antibody
Antibody SKU:	CAB15681
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human KCNA10 (NP_005540.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:	A-549

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human KCNA10 (NP_005540.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MDVC GWKE MEVA LVNF DNSD EIQE EPGY ATDF DSTS PKGR PGGS SFSN GKIL ISES TNHE TAFS KLPG DYAD PPGP EPVV LNEG NQRV IINI AGLR FETQ LRTL SQFP ETLL GDRE KRMQ FFDS M
Gene ID:	3744
Uniprot:	Q16322
Cellular Location:	Membrane, Multi-pass membrane protein
Calculated MW:	57kDa
Observed MW:	62kDa

Synonyms:

KCNA10, Kcn1, Kv1.8

Background:

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.

UniProt Protein Function:	KCNA10: Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily. Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP
UniProt Protein Details:	Protein type:Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: integral to membrane; plasma membrane; voltage-gated potassium channel complex Molecular Function:delayed rectifier potassium channel activity; intracellular cyclic nucleotide activated cation channel activity Biological Process: potassium ion transport; protein homooligomerization; synaptic transmission
NCBI Summary:	Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]
UniProt Code:	Q16322
NCBI GenInfo Identifier:	74739879
NCBI Gene ID:	3744
NCBI Accession:	Q16322.2
UniProt Related Accession:	Q16322
Molecular Weight:	57,785 Da
NCBI Full Name:	Potassium voltage-gated channel subfamily A member 10
NCBI Synonym Full Names:	potassium voltage-gated channel subfamily A member 10
NCBI Official Symbol:	KCNA10
NCBI Official Synonym Symbols:	Kcn1; Kv1.8
NCBI Protein Information:	potassium voltage-gated channel subfamily A member 10
UniProt Protein Name:	Potassium voltage-gated channel subfamily A member 10
UniProt Synonym Protein Names:	Voltage-gated potassium channel subunit Kv1.8
Protein Family:	Potassium voltage-gated channel subfamily
UniProt Gene Name:	KCNA10
UniProt Entry Name:	KCA10_HUMAN

Western blot analysis of extracts of A-549 cells, using KCNA10 antibody (CAB15681) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.

Antibodies

KCNA10 Antibody (PACO07191)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)