Cell Biology Antibodies 6

Anti-KAZN Antibody (CAB16028)

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SKU:
CAB16028
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-KAZN Antibody
Antibody SKU:CAB16028
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 586-775 of human KAZN (NP_963922.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-87MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 586-775 of human KAZN (NP_963922.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YQVN FSRE ALQE RRAR CETQ NIDP VVWT NQRV LKWV RDID LKEY ADNL TNSG VHGA VLVL EPTF NAEA MATA LGIP SGKH ILRR HLAE EMSA VFHP ANST GIRE AERF GTPP GRAS SVTR AGKE ENSS GLKY KAGR LPLG KIGR GFSS KDPD FHDD YGSL QNED CGDD DPQS RLEQ CRLE GYNS LEVT NV
Gene ID:23254
Uniprot:Q674X7
Cellular Location:
Calculated MW:37kDa/46kDa/86kDa
Observed MW:86kDa
Synonyms:KAZN, KAZ, kazrin
Background:This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified.
UniProt Protein Function:Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known.
NCBI Summary:This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. [provided by RefSeq, Aug 2011]
UniProt Code:Q674X7
NCBI GenInfo Identifier:172044653
NCBI Gene ID:23254
NCBI Accession:Q674X7.2
UniProt Secondary Accession:Q674X7,Q5TGF1, Q674X4, Q674X6, Q6ZUD1, Q8IYN7, Q8N409 Q9UIL2, Q9UPX4, B0QYQ0, B1AK78,
UniProt Related Accession:Q674X7
Molecular Weight:46,250 Da
NCBI Full Name:Kazrin
NCBI Synonym Full Names:kazrin, periplakin interacting protein
NCBI Official Symbol:KAZN  
NCBI Official Synonym Symbols:KAZ  
NCBI Protein Information:kazrin
UniProt Protein Name:Kazrin
Protein Family:Kazrin
UniProt Gene Name:KAZN  
UniProt Entry Name:KAZRN_HUMAN
Anti-KAZN Antibody (CAB16028)Western blot analysis of extracts of U-87MG cells, using KAZN antibody (CAB16028) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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