Epigenetics & Nuclear Signaling Antibodies 2

Anti-KAT7 Antibody (CAB5823)

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SKU:
CAB5823
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-KAT7 Antibody
Antibody SKU:CAB5823
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 55-193 of human KAT7 (NP_008998.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:BT-474, HepG2, 293T, HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 55-193 of human KAT7 (NP_008998.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DSSP VRNL QSFG TEEP AYST RRVT RSQQ QPTP VTPK KYPL RQTR SSGS ETEQ VVDF SDRE TKNT ADHD ESPP RTPT GNAP SSES DIDI SSPN VSHD ESIA KDMS LKDS GSDL SHRP KRRR FHES YNFN MKCP TPGC NSL
Gene ID:11143
Uniprot:O95251
Cellular Location:Nucleus, nucleoplasm
Calculated MW:51kDa/55kDa/58kDa/66kDa/70kDa
Observed MW:63kDa
Synonyms:KAT7, HBO1, HBOA, MYST2, ZC2HC7
Background:The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed.
UniProt Protein Function:MYST2: a histone acetyltransferase that participates in DNA replication and the loading of the minichromosome maintenance (Mcm) complex onto chromatin. Is required for origin recognition complex (Orc) formation and replication licensing, and is responsible for much of the acetylation of histone H4. Interacts with MCM2 and ORC1L. Phosphorylated by Cdc2 during mitosis, creating a site that recruits Plk1, which in turn phosphorylates MYST2. Its phosphorylation by Plk1 during mitosis may be required for the formation of the prereplicative complex. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. Specifically represses AR-mediated transcription.
UniProt Protein Details:

Protein type:EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Acetyltransferase

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: cytoplasm; histone acetyltransferase complex; nucleolus; nucleoplasm; nucleus

Molecular Function:protein binding

Biological Process: DNA replication

UniProt Code:O95251
NCBI GenInfo Identifier:68565854
NCBI Gene ID:11143
NCBI Accession:O95251.1
UniProt Secondary Accession:O95251,B3KN74, B4DF85, B4DFB4, B4DFE0, B4DGY4, E7ER15 G5E9K7,
UniProt Related Accession:O95251
Molecular Weight:55,135 Da
NCBI Full Name:Histone acetyltransferase KAT7
NCBI Synonym Full Names:lysine acetyltransferase 7
NCBI Official Symbol:KAT7  
NCBI Official Synonym Symbols:HBO1; HBOA; MYST2; ZC2HC7  
NCBI Protein Information:histone acetyltransferase KAT7
UniProt Protein Name:Histone acetyltransferase KAT7
UniProt Synonym Protein Names:Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST-2
Protein Family:Histone acetyltransferase
UniProt Gene Name:KAT7  
UniProt Entry Name:KAT7_HUMAN
Anti-KAT7 Antibody (CAB5823)Western blot analysis of extracts of various cell lines, using KAT7 antibody (CAB5823) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-KAT7 Antibody (CAB5823)Immunohistochemistry of paraffin-embedded rat spleen using KAT7 Rabbit pAb (CAB5823) at dilution of 1:100 (40x lens).
Anti-KAT7 Antibody (CAB5823)Immunohistochemistry of paraffin-embedded rat kidney using KAT7 Rabbit pAb (CAB5823) at dilution of 1:100 (40x lens).
Anti-KAT7 Antibody (CAB5823)Immunohistochemistry of paraffin-embedded human colon carcinoma using KAT7 Rabbit pAb (CAB5823) at dilution of 1:100 (40x lens).
Anti-KAT7 Antibody (CAB5823)Immunohistochemistry of paraffin-embedded human breast cancer using KAT7 Rabbit pAb (CAB5823) at dilution of 1:100 (40x lens).
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