Immunology Antibodies 2

Anti-KAT2A Antibody (CAB2224)

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SKU:
CAB2224
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:Anti-KAT2A Antibody
Antibody SKU:CAB2224
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human KAT2A (NP_066564.2).
Application:WB IHC IF
Recommended Dilution:WB 1:200 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, NIH/3T3, C6
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human KAT2A (NP_066564.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAEP SQAP TPAP AAQP RPLQ SPAP APTP TPAP SPAS APIP TPTP APAP APAA APAG STGT GGPG VGSG GAGS GGDP ARPG LSQQ QRAS QRKA QVRG LPRA
Gene ID:2648
Uniprot:Q92830
Cellular Location:Nucleus
Calculated MW:94kDa
Observed MW:110kDa
Synonyms:KAT2A, GCN5, GCN5L2, PCAF-b, hGCN5
Background:
UniProt Protein Function:GCN5: an ubiquitous histone acetyltransferase that promotes transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Interacts with P300, CBP, ADA2, and is a component of the TFTC-HAT complex. Two splice variant isoforms have been described.
UniProt Protein Details:

Protein type:EC 2.3.1.48; Acetyltransferase

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: extracellular space; nucleoplasm

Molecular Function:H3 histone acetyltransferase activity; histone acetyltransferase activity; histone deacetylase binding; protein binding; transcription coactivator activity; transcription factor binding

Biological Process: chromatin remodeling; histone deubiquitination; positive regulation of gene expression, epigenetic; regulation of protein stability; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter

NCBI Summary:KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
UniProt Code:Q92830
NCBI GenInfo Identifier:209572743
NCBI Gene ID:2648
NCBI Accession:Q92830.3
UniProt Secondary Accession:Q92830,Q8N1A2, Q9UCW1,
UniProt Related Accession:Q92830
Molecular Weight:48,921 Da
NCBI Full Name:Histone acetyltransferase KAT2A
NCBI Synonym Full Names:lysine acetyltransferase 2A
NCBI Official Symbol:KAT2A  
NCBI Official Synonym Symbols:GCN5; hGCN5; GCN5L2; PCAF-b  
NCBI Protein Information:histone acetyltransferase KAT2A
UniProt Protein Name:Histone acetyltransferase KAT2A
UniProt Synonym Protein Names:General control of amino acid synthesis protein 5-like 2; Histone acetyltransferase GCN5; HsGCN5; Lysine acetyltransferase 2A; STAF97
Protein Family:Histone acetyltransferase
UniProt Gene Name:KAT2A  
UniProt Entry Name:KAT2A_HUMAN
Anti-KAT2A Antibody (CAB2224)Western blot analysis of extracts of various cell lines, using KAT2A antibody (CAB2224) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-KAT2A Antibody (CAB2224)Immunohistochemistry of paraffin-embedded rat liver using KAT2A antibody (CAB2224) at dilution of 1:100 (40x lens).
Anti-KAT2A Antibody (CAB2224)Immunohistochemistry of paraffin-embedded rat kidney using KAT2A antibody (CAB2224) at dilution of 1:100 (40x lens).
Anti-KAT2A Antibody (CAB2224)Immunohistochemistry of paraffin-embedded human liver cancer using KAT2A antibody (CAB2224) at dilution of 1:100 (40x lens).
Anti-KAT2A Antibody (CAB2224)Immunofluorescence analysis of C6 cells using KAT2A Rabbit pAb (CAB2224) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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