Cell Biology Antibodies 17
Anti-KAT1 / HAT1 Antibody (CAB4423)
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- SKU:
- CAB4423
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-KAT1 / HAT1 Antibody |
| Antibody SKU: | CAB4423 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human KAT1 / HAT1 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, U-87MG, Mouse testis, Rat thymus |
| Immunogen: | A synthesized peptide derived from human KAT1 / HAT1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8520 |
| Uniprot: | O14929 |
| Cellular Location: | |
| Calculated MW: | 45kDa |
| Observed MW: | 49KDa |
| Synonyms: | KAT1 |
| Background: | The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009] |
| UniProt Protein Function: | HAT1: Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage. Belongs to the HAT1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Acetyltransferase; EC 2.3.1.48 Chromosomal Location of Human Ortholog: 2q31.2-q33.1 Cellular Component: intracellular membrane-bound organelle; nuclear chromatin; nuclear chromosome, telomeric region; nucleoplasm; nucleus; protein complex Molecular Function:H4 histone acetyltransferase activity; histone acetyltransferase activity; histone binding; protein binding Biological Process: DNA packaging; DNA replication-dependent nucleosome assembly; DNA replication-independent nucleosome assembly; internal protein amino acid acetylation |
| NCBI Summary: | The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009] |
| UniProt Code: | O14929 |
| NCBI GenInfo Identifier: | 3334209 |
| NCBI Gene ID: | 8520 |
| NCBI Accession: | O14929.1 |
| UniProt Secondary Accession: | O14929,Q49A44, Q53QF0, Q53SU4, Q6P594, Q8WWB9, |
| UniProt Related Accession: | O14929 |
| Molecular Weight: | 39,786 Da |
| NCBI Full Name: | Histone acetyltransferase type B catalytic subunit |
| NCBI Synonym Full Names: | histone acetyltransferase 1 |
| NCBI Official Symbol: | HAT1 |
| NCBI Official Synonym Symbols: | KAT1 |
| NCBI Protein Information: | histone acetyltransferase type B catalytic subunit |
| UniProt Protein Name: | Histone acetyltransferase type B catalytic subunit |
| UniProt Synonym Protein Names: | Histone acetyltransferase 1 |
| Protein Family: | HAT1-interacting factor |
| UniProt Gene Name: | HAT1 |
| UniProt Entry Name: | HAT1_HUMAN |
 | Western blot - KAT1 / HAT1 Rabbit mAb (CAB4423) |
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