| UniProt Protein Function: | TIF1B: an atypical protein kinase that functions as a transcriptional coactivator. Mediates transcriptional regulation by interaction with the Kruppel-associated box (KRAB) repression domain found in many transcription factors. Binds to the negative regulatory domain of c-Myb and negatively regulates the c-Myb-dependent trans-activation. Localizes to the nucleus and is thought to associate with specific chromatin regions. Phosphorylated in an ATM-dependent manner following double-strand breaks. Its phosphorylation in response to DNA damage leads to chromatin relaxation. A member of the tripartite motif family. The tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. |
| UniProt Protein Details: | Protein type:EC 6.3.2.-; Ligase; Protein kinase, atypical; Ubiquitin conjugating system; Kinase, protein; Ubiquitin ligase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; ATYPICAL group; TIF1 family Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: nucleoplasm; nuclear heterochromatin; nucleus Molecular Function:protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; ubiquitin protein ligase binding; transcription coactivator activity; ubiquitin-protein ligase activity; transcription factor activity; transcription corepressor activity; ligase activity; protein kinase activity Biological Process: transcription initiation from RNA polymerase II promoter; convergent extension involved in axis elongation; positive regulation of DNA repair; protein amino acid autophosphorylation; positive regulation of transcription, DNA-dependent; protein ubiquitination; negative regulation of transcription from RNA polymerase II promoter; DNA repair; protein oligomerization; protein sumoylation; positive regulation of transcription factor import into nucleus; innate immune response; epithelial to mesenchymal transition; gene expression; negative regulation of transcription, DNA-dependent; DNA methylation during embryonic development; embryo implantation |
| NCBI Summary: | The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13263 |
| NCBI GenInfo Identifier: | 3183179 |
| NCBI Gene ID: | 10155 |
| NCBI Accession: | Q13263.5 |
| UniProt Secondary Accession: | Q13263,O00677, Q7Z632, Q93040, Q96IM1, |
| UniProt Related Accession: | Q13263 |
| Molecular Weight: | 835 |
| NCBI Full Name: | Transcription intermediary factor 1-beta |
| NCBI Synonym Full Names: | tripartite motif containing 28 |
| NCBI Official Symbol: | TRIM28 |
| NCBI Official Synonym Symbols: | KAP1; TF1B; RNF96; TIF1B; PPP1R157 |
| NCBI Protein Information: | transcription intermediary factor 1-beta; KAP-1; KRIP-1; TIF1-beta; RING finger protein 96; KRAB-associated protein 1; nuclear corepressor KAP-1; KRAB-interacting protein 1; E3 SUMO-protein ligase TRIM28; tripartite motif-containing 28; tripartite motif-c |
| UniProt Protein Name: | Transcription intermediary factor 1-beta |
| UniProt Synonym Protein Names: | E3 SUMO-protein ligase TRIM28 (EC:6.3.2.-); KRAB-associated protein 1; KAP-1; KRAB-interacting protein 1; KRIP-1; Nuclear corepressor KAP-1; RING finger protein 96; Tripartite motif-containing protein 28 |
| UniProt Gene Name: | TRIM28 |
| UniProt Entry Name: | TIF1B_HUMAN |
