Cell Biology Antibodies 1

Anti-JPH4 Antibody (CAB10333)

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SKU:
CAB10333
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-JPH4 Antibody
Antibody SKU:CAB10333
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 405-605 of human JPH4 (NP_115828.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, HT-1080, HepG2, 293T, Mouse liver, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 405-605 of human JPH4 (NP_115828.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AARM AKLI AQDL QPML EAPG RRPR QDSE GSDT EPLD EDSP GVYE NGLT PSEG SPEL PSSP ASSR QPWR PPAC RSPL PPGG DQGP FSSP KAWP EEWG GAGA QAEE LAGY EAED EAGM QGPG PRDG SPLL GGCS DSSG SLRE EEGE DEEP LPPL RAPA GTEP EPIA MLVL RGSS SRGP DAGC LTEE LGEP AATE RPAQ PGAA N
Gene ID:84502
Uniprot:Q96JJ6
Cellular Location:Cell membrane, Endoplasmic reticulum membrane, Peripheral membrane protein, Single-pass type IV membrane protein
Calculated MW:65kDa
Observed MW:85kDa
Synonyms:JPH4, JP4, JPHL1
Background:This gene encodes a member of the junctophilin family of transmembrane proteins that are involved in the formation of the junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum in excitable cells. The encoded protein contains a conserved N-terminal repeat region called the membrane occupation and recognition nexus sequence that is found in other members of the junctophilin family. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:JPH4: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. Belongs to the junctophilin family.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q11.2

NCBI Summary:This gene encodes a member of the junctophilin family of transmembrane proteins that are involved in the formation of the junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum in excitable cells. The encoded protein contains a conserved N-terminal repeat region called the membrane occupation and recognition nexus sequence that is found in other members of the junctophilin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
UniProt Code:Q96JJ6
NCBI GenInfo Identifier:34582362
NCBI Gene ID:84502
NCBI Accession:Q96JJ6.2
UniProt Secondary Accession:Q96JJ6,Q8ND44, Q96DQ0, D3DS53,
UniProt Related Accession:Q96JJ6
Molecular Weight:66kDa
NCBI Full Name:Junctophilin-4
NCBI Synonym Full Names:junctophilin 4
NCBI Official Symbol:JPH4  
NCBI Official Synonym Symbols:JP4; JPHL1  
NCBI Protein Information:junctophilin-4
UniProt Protein Name:Junctophilin-4
UniProt Synonym Protein Names:Junctophilin-like 1 protein
Protein Family:Junctophilin
UniProt Gene Name:JPH4  
Anti-JPH4 Antibody (CAB10333)Western blot analysis of extracts of various cell lines, using JPH4 antibody (CAB10333) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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