| UniProt Protein Function: | TRIP8: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes. Belongs to the JHDM2 histone demethylase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.14.11.-; Demethylase; Oxidoreductase; Nuclear receptor co-regulator; Transcription, coactivator/corepressorChromosomal Location of Human Ortholog: 10q21.3Cellular Component: nucleoplasmMolecular Function: histone demethylase activity (H3-K9 specific); protein binding; thyroid hormone receptor bindingBiological Process: blood coagulation; regulation of transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q15652 |
| NCBI GenInfo Identifier: | 85541650 |
| NCBI Gene ID: | 221037 |
| NCBI Accession: | Q15652.2 |
| UniProt Secondary Accession: | Q15652,Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9 Q9P2G7, A0T124 |
| UniProt Related Accession: | Q15652 |
| Molecular Weight: | 263,157 Da |
| NCBI Full Name: | Probable JmjC domain-containing histone demethylation protein 2C |
| NCBI Synonym Full Names: | jumonji domain containing 1C |
| NCBI Official Symbol: | JMJD1C |
| NCBI Official Synonym Symbols: | TRIP8; TRIP-8 |
| NCBI Protein Information: | probable JmjC domain-containing histone demethylation protein 2C |
| UniProt Protein Name: | Probable JmjC domain-containing histone demethylation protein 2C |
| UniProt Synonym Protein Names: | Jumonji domain-containing protein 1C; Thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8 |
| Protein Family: | Probable JmjC domain-containing histone demethylation protein |
| UniProt Gene Name: | JMJD1C |
| UniProt Entry Name: | JHD2C_HUMAN |
