Cell Biology Antibodies 4
Anti-JAM2 Antibody (CAB14145)
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- SKU:
- CAB14145
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-JAM2 Antibody |
| Antibody SKU: | CAB14145 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-238 of human JAM2 (NP_067042.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, SH-SY5Y, A-431, HeLa, Mouse brain, Mouse heart, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-238 of human JAM2 (NP_067042.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FSAP KDQQ VVTA VEYQ EAIL ACKT PKKT VSSR LEWK KLGR SVSF VYYQ QTLQ GDFK NRAE MIDF NIRI KNVT RSDA GKYR CEVS APSE QGQN LEED TVTL EVLV APAV PSCE VPSS ALSG TVVE LRCQ DKEG NPAP EYTW FKDG IRLL ENPR LGSQ STNS SYTM NTKT GTLQ FNTV SKLD TGEY SCEA RNSV GYRR CPGK RMQV DDLN IS |
| Gene ID: | 58494 |
| Uniprot: | P57087 |
| Cellular Location: | Cell junction, Cell membrane, Single-pass type I membrane protein, tight junction |
| Calculated MW: | 29kDa/33kDa/34kDa |
| Observed MW: | 45kDa |
| Synonyms: | JAM2, C21orf43, CD322, JAM-B, JAMB, PRO245, VE-JAM, VEJAM |
| Background: | This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | May play a role in the processes of lymphocyte homing to secondary lymphoid organs. |
| NCBI Summary: | This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Code: | P57087 |
| NCBI GenInfo Identifier: | 10720348 |
| NCBI Gene ID: | 58494 |
| NCBI Accession: | P57087.1 |
| UniProt Secondary Accession: | P57087,Q6UXG6, Q6YNC1, B2R6T9, B4DGT9, |
| UniProt Related Accession: | P57087 |
| Molecular Weight: | 34,554 Da |
| NCBI Full Name: | Junctional adhesion molecule B |
| NCBI Synonym Full Names: | junctional adhesion molecule 2 |
| NCBI Official Symbol: | JAM2 |
| NCBI Official Synonym Symbols: | JAMB; CD322; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43 |
| NCBI Protein Information: | junctional adhesion molecule B |
| UniProt Protein Name: | Junctional adhesion molecule B |
| UniProt Synonym Protein Names: | Junctional adhesion molecule 2; JAM-2; Vascular endothelial junction-associated molecule; VE-JAM; CD_antigen: CD322 |
| Protein Family: | Junctional adhesion molecule |
| UniProt Gene Name: | JAM2 |
 | Western blot analysis of extracts of various cell lines, using JAM2 antibody (CAB14145) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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