Cell Biology Antibodies 1
Anti-JAK1 Antibody (CAB0715)
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- SKU:
- CAB0715
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-JAK1 Antibody |
| Antibody SKU: | CAB0715 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human JAK1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, Jurkat, U-87MG, LO2 |
| Immunogen: | A synthetic peptide of human JAK1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3716 |
| Uniprot: | P23458 |
| Cellular Location: | Endomembrane system, Peripheral membrane protein |
| Calculated MW: | 133kDa |
| Observed MW: | 115kDa |
| Synonyms: | JAK1, JAK1A, JAK1B, JTK3 |
| Background: | This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | JAK1: a widely expressed non-receptor tyrosine-kinase involved in the interferon-alpha/beta and -gamma signal transduction pathways. Couples cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. A selective Jak1 inhibitor induces apoptosis in NRP-154 prostate cancer cell line. A single mutation seen in tyrosine kinome screen of colon cancers. Activated in B cell lines from patients with post-transplant lymphoproliferative disorder, and in a mouse Lck-driven T cell lymphoma. Inhibitor: Piceatannol. |
| UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.10.2; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; JakA family Chromosomal Location of Human Ortholog: 1p32.3-p31.3 Cellular Component: cytoplasm; cytoskeleton; cytosol; endomembrane system; extrinsic to internal side of plasma membrane; focal adhesion; nucleus Molecular Function:ATP binding; CCR5 chemokine receptor binding; growth hormone receptor binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein phosphatase binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding; ubiquitin protein ligase binding Biological Process: cell differentiation; cell migration; innate immune response; MAPKKK cascade; positive regulation of GTPase activity; protein amino acid phosphorylation; regulation of cell proliferation; response to antibiotic; transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Code: | P23458 |
| NCBI GenInfo Identifier: | 215274013 |
| NCBI Gene ID: | 3716 |
| NCBI Accession: | P23458.2 |
| UniProt Secondary Accession: | P23458,Q59GQ2, Q9UD26, |
| UniProt Related Accession: | P23458 |
| Molecular Weight: | |
| NCBI Full Name: | Tyrosine-protein kinase JAK1 |
| NCBI Synonym Full Names: | Janus kinase 1 |
| NCBI Official Symbol: | JAK1 |
| NCBI Official Synonym Symbols: | JTK3; JAK1A; JAK1B |
| NCBI Protein Information: | tyrosine-protein kinase JAK1 |
| UniProt Protein Name: | Tyrosine-protein kinase JAK1 |
| UniProt Synonym Protein Names: | Janus kinase 1; JAK-1 |
| Protein Family: | Tyrosine-protein kinase |
| UniProt Gene Name: | JAK1 |
| UniProt Entry Name: | JAK1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using JAK1 antibody (CAB0715) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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