Anti-JAG2 Antibody (CAB19267)
- SKU:
- CAB19267
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- JAG2
- Synonyms:
- HJ2
- Synonyms:
- SER2
- Synonyms:
- jagged 2
Description
| Product Name: | JAG2 Rabbit mAb |
| Product Code: | CAB19267 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | JAG2, HJ2, SER2, jagged 2 |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human JAG2. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Immunogen: | Recombinant protein of human JAG2. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3714 |
| Uniprot: | Q9Y219 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 145kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | JAG2: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development. Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell surface Chromosomal Location of Human Ortholog: 14q32 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:protein binding; growth factor activity; calcium ion binding; Notch binding Biological Process: regulation of cell adhesion; thymic T cell selection; Notch signaling pathway; in utero embryonic development; Notch receptor processing; cell cycle; regulation of cell migration; odontogenesis of dentine-containing teeth; regulation of cell proliferation; respiratory system process; morphogenesis of embryonic epithelium; spermatogenesis; cell differentiation; auditory receptor cell fate commitment; skeletal development; gamma-delta T cell differentiation; T cell differentiation |
| NCBI Summary: | The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y219 |
| NCBI GenInfo Identifier: | 21704277 |
| NCBI Gene ID: | 3714 |
| NCBI Accession: | NP_002217.3 |
| UniProt Secondary Accession: | Q9Y219,Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0, |
| UniProt Related Accession: | Q9Y219 |
| Molecular Weight: | |
| NCBI Full Name: | protein jagged-2 isoform a |
| NCBI Synonym Full Names: | jagged 2 |
| NCBI Official Symbol: | JAG2 |
| NCBI Official Synonym Symbols: | HJ2; SER2 |
| NCBI Protein Information: | protein jagged-2 |
| UniProt Protein Name: | Protein jagged-2 |
| Protein Family: | Protein jagged |
| UniProt Gene Name: | JAG2 |
| UniProt Entry Name: | JAG2_HUMAN |
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