Signal Transduction Antibodies 1

Anti-JAG2 Antibody (CAB14247)

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SKU:
CAB14247
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-JAG2 Antibody
Antibody SKU:CAB14247
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-200 of human JAG2 (NP_002217.3).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse thymus, Rat thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-200 of human JAG2 (NP_002217.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ARPM GYFE LQLS ALRN VNGE LLSG ACCD GDGR TTRA GGCG HDEC DTYV RVCL KEYQ AKVT PTGP CSYG HGAT PVLG GNSF YLPP AGAA GDRA RARA RAGG DQDP GLVV IPFQ FAWP RSFT LIVE AWDW DNDT TPNE ELLI ERVS HAGM INPE DRWK SLHF SGHV AHLE LQIR VRCD E
Gene ID:3714
Uniprot:Q9Y219
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:129kDa/133kDa
Observed MW:175kDa
Synonyms:JAG2, HJ2, SER2, jagged 2
Background:The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:JAG2: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development. Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:protein binding; growth factor activity; calcium ion binding; Notch binding

Biological Process: regulation of cell adhesion; thymic T cell selection; Notch signaling pathway; in utero embryonic development; Notch receptor processing; cell cycle; regulation of cell migration; odontogenesis of dentine-containing teeth; regulation of cell proliferation; respiratory system process; morphogenesis of embryonic epithelium; spermatogenesis; cell differentiation; auditory receptor cell fate commitment; skeletal development; gamma-delta T cell differentiation; T cell differentiation

NCBI Summary:The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y219
NCBI GenInfo Identifier:21704277
NCBI Gene ID:3714
NCBI Accession:NP_002217.3
UniProt Secondary Accession:Q9Y219,Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0,
UniProt Related Accession:Q9Y219
Molecular Weight:
NCBI Full Name:protein jagged-2 isoform a
NCBI Synonym Full Names:jagged 2
NCBI Official Symbol:JAG2  
NCBI Official Synonym Symbols:HJ2; SER2  
NCBI Protein Information:protein jagged-2
UniProt Protein Name:Protein jagged-2
Protein Family:Protein jagged
UniProt Gene Name:JAG2  
UniProt Entry Name:JAG2_HUMAN
Anti-JAG2 Antibody (CAB14247)Western blot analysis of extracts of various cell lines, using JAG2 antibody (CAB14247) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-JAG2 Antibody (CAB14247)Immunofluorescence analysis of C6 cells using JAG2 antibody (CAB14247) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-JAG2 Antibody (CAB14247)Immunofluorescence analysis of L929 cells using JAG2 antibody (CAB14247) at dilution of 1:100. Blue: DAPI for nuclear staining.
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