| UniProt Protein Function: | ITSN1: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GEFs, Rac/Rho; GEFs; Calcium-binding; Adaptor/scaffold Chromosomal Location of Human Ortholog: 21q22.1-q22.2 Cellular Component: neuron projection; endocytic vesicle; lamellipodium; plasma membrane; synapse; coated pit; cytosol; cell junction Molecular Function:Rho guanyl-nucleotide exchange factor activity; protein binding; guanyl-nucleotide exchange factor activity; kinase activator activity; calcium ion binding; protein complex scaffold Biological Process: positive regulation of protein kinase B signaling cascade; axon guidance; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; synaptic vesicle endocytosis; ephrin receptor signaling pathway; negative regulation of neuron apoptosis; positive regulation of phosphorylation; positive regulation of GTPase activity |
| NCBI Summary: | The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15811 |
| NCBI GenInfo Identifier: | 115527782 |
| NCBI Gene ID: | 6453 |
| NCBI Accession: | BC116186 |
| UniProt Secondary Accession: | Q15811,A7Y322, A8CTX8, A8CTY3, A8CTY7, A8D7D0, A8DCP3 B4DTM2, E7ERJ1, E9PE44, E9PG01, E9PHV2, |
| UniProt Related Accession: | Q15811 |
| Molecular Weight: | 104,194 Da |
| NCBI Full Name: | Homo sapiens intersectin 1 (SH3 domain protein), mRNA |
| NCBI Synonym Full Names: | intersectin 1 (SH3 domain protein) |
| NCBI Official Symbol: | ITSN1 |
| NCBI Official Synonym Symbols: | ITSN; SH3D1A; SH3P17 |
| NCBI Protein Information: | intersectin-1; SH3 domain-containing protein 1A; Src homology 3 domain-containing protein; human intersectin-SH3 domain-containing protein SH3P17; intersectin 1 short form variant 3; intersectin 1 short form variant, 11; intersectin short variant 12 |
| UniProt Protein Name: | Intersectin-1 |
| UniProt Synonym Protein Names: | SH3 domain-containing protein 1A; SH3P17 |
| Protein Family: | Intersectin |
| UniProt Gene Name: | ITSN1 |
| UniProt Entry Name: | ITSN1_HUMAN |
