Cell Biology Antibodies 12
Anti-ITPK1 Antibody (CAB8312)
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- SKU:
- CAB8312
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | ITPK1 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8312 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 185-414 of human ITPK1 (NP_055031.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HepG2, Mouse testis, Mouse brain, Mouse intestine, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 185-414 of human ITPK1 (NP_055031.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | CVVQ NFIN HNAV LYKV FVVG ESYT VVQR PSLK NFSA GTSD RESI FFNS HNVS KPES SSVL TELD KIEG VFER PSDE VIRE LSRA LRQA LGVS LFGI DIII NNQT GQHA VIDI NAFP GYEG VSEF FTDL LNHI ATVL QGQS TAMA ATGD VALL RHSK LLAE PAGG LVGE RTCS ASPG CCGS MMGQ DAPW KAEA DAGG TAKL PHQR LGCN AGVS PSFQ QHCV ASLA TKAS SQ |
| Gene ID: | 3705 |
| Uniprot: | Q13572 |
| Cellular Location: | |
| Calculated MW: | 35kDa/45kDa |
| Observed MW: | 39kDa |
| Synonyms: | ITPK1, ITRPK1 |
| Background: |
| UniProt Protein Function: | ITPK1: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. Belongs to the ITPK1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; Kinase, lipid; EC 2.7.1.134; EC 2.7.1.159 Chromosomal Location of Human Ortholog: 14q31 Cellular Component: cytosol Molecular Function:catalytic activity; inositol tetrakisphosphate 1-kinase activity Biological Process: blood coagulation; inositol phosphate metabolic process; signal transduction |
| NCBI Summary: | This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q13572 |
| NCBI GenInfo Identifier: | 83288249 |
| NCBI Gene ID: | 3705 |
| NCBI Accession: | Q13572.2 |
| UniProt Secondary Accession: | Q13572,Q9BTL6, Q9H2E7, |
| UniProt Related Accession: | Q13572 |
| Molecular Weight: | 35,632 Da |
| NCBI Full Name: | Inositol-tetrakisphosphate 1-kinase |
| NCBI Synonym Full Names: | inositol-tetrakisphosphate 1-kinase |
| NCBI Official Symbol: | ITPK1 |
| NCBI Official Synonym Symbols: | ITRPK1 |
| NCBI Protein Information: | inositol-tetrakisphosphate 1-kinase |
| UniProt Protein Name: | Inositol-tetrakisphosphate 1-kinase |
| UniProt Synonym Protein Names: | Inositol 1,3,4-trisphosphate 5/6-kinase (EC:2.7.1.159); Inositol-triphosphate 5/6-kinase; Ins(1,3,4)P(3) 5/6-kinase |
| Protein Family: | Inositol-tetrakisphosphate 1-kinase |
| UniProt Gene Name: | ITPK1 |
| UniProt Entry Name: | ITPK1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ITPK1 antibody (CAB8312) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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