Cell Biology Antibodies 3
Anti-ITM2C Antibody (CAB12675)
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- SKU:
- CAB12675
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ITM2C Antibody |
| Antibody SKU: | CAB12675 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ITM2C (NP_001012532.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ITM2C (NP_001012532.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVKI SFQP AVAG IKGD KADK ASAS APAP ASAT EILL TPAR LARD NFFR CGVL YEDS LSSQ VRTQ MELE EDVK IYLD ENYE RINV PVPQ FGGG DPAD IIHD FQRG LTAY HDIS LDKC YVIE LNTT IVLP PRNF WELL MNVK RGTY LPQT YIIQ EEMV VTEH VSDK EALG SFIY HLCN GKDT YRLR RRAT RRRI NKRG AKNC NAIR HFEN TFVV ETLI CGVV |
| Gene ID: | 81618 |
| Uniprot: | Q9NQX7 |
| Cellular Location: | Cell membrane, Lysosome membrane, Single-pass type II membrane protein |
| Calculated MW: | 24kDa/25kDa/30kDa |
| Observed MW: | 30kDa |
| Synonyms: | ITM2C, BRI3, BRICD2C, E25, E25C, ITM3 |
| Background: |
| UniProt Protein Function: | ITM2C: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. Belongs to the ITM2 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 2q37.1 Cellular Component: Golgi apparatus; lysosome; perinuclear region of cytoplasm; plasma membrane Molecular Function:beta-amyloid binding; protein binding Biological Process: neuron differentiation |
| UniProt Code: | Q9NQX7 |
| NCBI GenInfo Identifier: | 12585259 |
| NCBI Gene ID: | 81618 |
| NCBI Accession: | Q9NQX7.1 |
| UniProt Secondary Accession: | Q9NQX7,Q4G0A8, Q53H84, Q6IAE7, Q86VK5, Q8N288, Q8TAW0 Q9BUP8, B3KPG4, |
| UniProt Related Accession: | Q9NQX7 |
| Molecular Weight: | 30kDa |
| NCBI Full Name: | Integral membrane protein 2C |
| NCBI Synonym Full Names: | integral membrane protein 2C |
| NCBI Official Symbol: | ITM2C |
| NCBI Official Synonym Symbols: | E25; BRI3; E25C; ITM3; BRICD2C |
| NCBI Protein Information: | integral membrane protein 2C |
| UniProt Protein Name: | Integral membrane protein 2C |
| UniProt Synonym Protein Names: | Cerebral protein 14; Transmembrane protein BRI3 |
| Protein Family: | Integral membrane protein |
| UniProt Gene Name: | ITM2C |
 | Western blot analysis of extracts of various cell lines, using ITM2C antibody (CAB12675) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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