Cell Biology Antibodies 3

Anti-ITM2C Antibody (CAB12675)

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SKU:
CAB12675

Description

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Antibody Name:Anti-ITM2C Antibody
Antibody SKU:CAB12675
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ITM2C (NP_001012532.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ITM2C (NP_001012532.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVKI SFQP AVAG IKGD KADK ASAS APAP ASAT EILL TPAR LARD NFFR CGVL YEDS LSSQ VRTQ MELE EDVK IYLD ENYE RINV PVPQ FGGG DPAD IIHD FQRG LTAY HDIS LDKC YVIE LNTT IVLP PRNF WELL MNVK RGTY LPQT YIIQ EEMV VTEH VSDK EALG SFIY HLCN GKDT YRLR RRAT RRRI NKRG AKNC NAIR HFEN TFVV ETLI CGVV
Gene ID:81618
Uniprot:Q9NQX7
Cellular Location:Cell membrane, Lysosome membrane, Single-pass type II membrane protein
Calculated MW:24kDa/25kDa/30kDa
Observed MW:30kDa
Synonyms:ITM2C, BRI3, BRICD2C, E25, E25C, ITM3
Background:
UniProt Protein Function:ITM2C: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. Belongs to the ITM2 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: Golgi apparatus; lysosome; perinuclear region of cytoplasm; plasma membrane

Molecular Function:beta-amyloid binding; protein binding

Biological Process: neuron differentiation

UniProt Code:Q9NQX7
NCBI GenInfo Identifier:12585259
NCBI Gene ID:81618
NCBI Accession:Q9NQX7.1
UniProt Secondary Accession:Q9NQX7,Q4G0A8, Q53H84, Q6IAE7, Q86VK5, Q8N288, Q8TAW0 Q9BUP8, B3KPG4,
UniProt Related Accession:Q9NQX7
Molecular Weight:30kDa
NCBI Full Name:Integral membrane protein 2C
NCBI Synonym Full Names:integral membrane protein 2C
NCBI Official Symbol:ITM2C  
NCBI Official Synonym Symbols:E25; BRI3; E25C; ITM3; BRICD2C  
NCBI Protein Information:integral membrane protein 2C
UniProt Protein Name:Integral membrane protein 2C
UniProt Synonym Protein Names:Cerebral protein 14; Transmembrane protein BRI3
Protein Family:Integral membrane protein
UniProt Gene Name:ITM2C  
Anti-ITM2C Antibody (CAB12675)Western blot analysis of extracts of various cell lines, using ITM2C antibody (CAB12675) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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Additional Information

Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
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