Cell Biology Antibodies 5
Anti-ITM2B Antibody (CAB14824)
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- SKU:
- CAB14824
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ITM2B Antibody |
| Antibody SKU: | CAB14824 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 81-266 of human ITM2B (NP_068839.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Mouse brain, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 81-266 of human ITM2B (NP_068839.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LQPD DVYY CGIK YIKD DVIL NEPS ADAP AALY QTIE ENIK IFEE EEVE FISV PVPE FADS DPAN IVHD FNKK LTAY LDLN LDKC YVIP LNTS IVMP PRNL LELL INIK AGTY LPQS YLIH EHMV ITDR IENI DHLG FFIY RLCH DKET YKLQ RRET IKGI QKRE ASNC FAIR HFEN KFAV ETLI CS |
| Gene ID: | 9445 |
| Uniprot: | Q9Y287 |
| Cellular Location: | Cell membrane, Endosome membrane, Golgi apparatus membrane, Secreted, Single-pass type II membrane protein, Single-pass type II membrane protein |
| Calculated MW: | 18kDa/30kDa |
| Observed MW: | 30kDa |
| Synonyms: | ITM2B, ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, RDGCA, imBRI2 |
| Background: | Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. |
| UniProt Protein Function: | ITM2B: Plays a regulatory role in the processing of the beta- amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites. Defects in ITM2B are a cause of cerebral amyloid angiopathy ITM2B-related type 1 (CAA-ITM2B1). A disorder characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervous system. Cerebral amyloid angiopathy, non-neuritic and perivascular plaques and neurofibrillary tangles are the predominant pathological lesions. Clinical features include progressive mental deterioration, spasticity and muscular rigidity. ABri amyloidogenic peptide variant is cleaved at the normal furin processing site to generate peptide that accumulates in the brain and produces amyloid fibrils responsible for neuronal dysfunction and dementia. ABri peptide variant forms fibrila in vitro. Defects in ITM2B are a cause of cerebral amyloid angiopathy ITM2B-related type 2 (CAA-ITM2B2); also known as heredopathia ophthalmo-oto-encephalica. A disorder characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina. Plaques and neurofibrillary tangles are observed in the hippocampus. Clinical features include progressive ataxia, dementia, cataracts and deafness. ADan amyloidogenic peptide variant is cleaved at the normal furin processing site to generate peptide that accumulates in the brain and produces amyloid fibrils responsible for neuronal dysfunction and dementia. Belongs to the ITM2 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 13q14.3 Cellular Component: extracellular region; extracellular space; Golgi apparatus; intracellular membrane-bound organelle; membrane; plasma membrane Molecular Function:beta-amyloid binding; protein binding Biological Process: cellular protein metabolic process; negative regulation of amyloid precursor protein biosynthetic process; nervous system development Disease: Cerebral Amyloid Angiopathy, Itm2b-related, 1; Cerebral Amyloid Angiopathy, Itm2b-related, 2; Retinal Dystrophy With Inner Retinal Dysfunction And Ganglion Cell Abnormalities |
| NCBI Summary: | Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9Y287 |
| NCBI GenInfo Identifier: | 12643343 |
| NCBI Gene ID: | 9445 |
| NCBI Accession: | Q9Y287.1 |
| UniProt Secondary Accession: | Q9Y287,Q5W0A3, Q96B24, Q9NYH1, |
| UniProt Related Accession: | Q9Y287 |
| Molecular Weight: | 18,283 Da |
| NCBI Full Name: | Integral membrane protein 2B |
| NCBI Synonym Full Names: | integral membrane protein 2B |
| NCBI Official Symbol: | ITM2B |
| NCBI Official Synonym Symbols: | BRI; FBD; ABRI; BRI2; E25B; E3-16; RDGCA; imBRI2; BRICD2B |
| NCBI Protein Information: | integral membrane protein 2B |
| UniProt Protein Name: | Integral membrane protein 2B |
| UniProt Synonym Protein Names: | Immature BRI2; imBRI2 |
| Protein Family: | Integral membrane protein |
| UniProt Gene Name: | ITM2B |
| UniProt Entry Name: | ITM2B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ITM2B antibody (CAB14824) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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