Immunology Antibodies 1
Anti-ITK Antibody (CAB12682)
- SKU:
- CAB12682
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-ITK Antibody |
| Antibody SKU: | CAB12682 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-620 of human ITK (NP_005537.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:3000 |
| Reactivity: | Human |
| Positive Samples: | MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-620 of human ITK (NP_005537.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QRGL FAAE TLLG MCLD VCEG MAYL EEAC VIHR DLAA RNCL VGEN QVIK VSDF GMTR FVLD DQYT SSTG TKFP VKWA SPEV FSFS RYSS KSDV WSFG VLMW EVFS EGKI PYEN RSNS EVVE DIST GFRL YKPR LAST HVYQ IMNH CWKE RPED RPAF SRLL RQLA EIAE SGL |
| Gene ID: | 3702 |
| Uniprot: | Q08881 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 71kDa |
| Observed MW: | 72kDa |
| Synonyms: | ITK, EMT, LPFS1, LYK, PSCTK2 |
| Background: | This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. |
| UniProt Code: | Q08881 |
| NCBI GenInfo Identifier: | 585361 |
| NCBI Gene ID: | 3702 |
| NCBI Accession: | Q08881.1 |
| UniProt Secondary Accession: | Q08881,Q32ML7, B2R752, |
| UniProt Related Accession: | Q08881 |
| Molecular Weight: | 620 |
| NCBI Full Name: | Tyrosine-protein kinase ITK/TSK |
| NCBI Synonym Full Names: | IL2-inducible T-cell kinase |
| NCBI Official Symbol: | ITK |
| NCBI Official Synonym Symbols: | EMT; LYK; LPFS1; PSCTK2 |
| NCBI Protein Information: | tyrosine-protein kinase ITK/TSK; kinase EMT; T-cell-specific kinase; tyrosine-protein kinase LYK; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; homolog of mouse T-cell itk/tsk; interleukin-2-inducible T cell kinase; interleukin-2-inducible T |
| UniProt Protein Name: | Tyrosine-protein kinase ITK/TSK |
| UniProt Synonym Protein Names: | Interleukin-2-inducible T-cell kinase; IL-2-inducible T-cell kinase; Kinase EMT; T-cell-specific kinase; Tyrosine-protein kinase Lyk |
| Protein Family: | Tyrosine-protein kinase |
| UniProt Gene Name: | ITK |
| UniProt Entry Name: | ITK_HUMAN |
 | Western blot analysis of extracts of MCF-7 cells, using ITK antibody (CAB12682) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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