Immunology Antibodies 1

Anti-ITIH4 Antibody (CAB12807)

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SKU:
CAB12807
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-ITIH4 Antibody
Antibody SKU:CAB12807
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 689-930 of human ITIH4 (NP_002209.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:LO2, A-549
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 689-930 of human ITIH4 (NP_002209.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RLAI LPAS APPA TSNP DPAV SRVM NMKI EETT MTTQ TPAP IQAP SAIL PLPG QSVE RLCV DPRH RQGP VNLL SDPE QGVE VTGQ YERE KAGF SWIE VTFK NPLV WVHA SPEH VVVT RNRR SSAY KWKE TLFS VMPG LKMT MDKT GLLL LSDP DKVT IGLL FWDG RGEG LRLL LRDT DRFS SHVG GTLG QFYQ EVLW GSPA ASDD GRRT LRVQ GNDH SATR ERRL DYQE GPPG VEIS CWSV EL
Gene ID:3700
Uniprot:Q14624
Cellular Location:Secreted
Calculated MW:93kDa/99kDa/101kDa/103kDa
Observed MW:103kDa
Synonyms:ITIH4, GP120, H4P, IHRP, ITI-HC4, ITIHL1, PK-120, PK120
Background:The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:ITIH4: May be involved in acute phase reactions. Belongs to the ITIH family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: extracellular region

Molecular Function:endopeptidase inhibitor activity; protein binding

Biological Process: acute-phase response; platelet degranulation; response to cytokine stimulus

Disease: Hypercholesterolemia, Familial

NCBI Summary:The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
UniProt Code:Q14624
NCBI GenInfo Identifier:229463048
NCBI Gene ID:3700
NCBI Accession:Q14624.4
UniProt Secondary Accession:Q14624,Q15135, Q9P190, Q9UQ54, B7Z545, E9PGN5,
UniProt Related Accession:Q14624
Molecular Weight:93,852 Da
NCBI Full Name:Inter-alpha-trypsin inhibitor heavy chain H4
NCBI Synonym Full Names:inter-alpha-trypsin inhibitor heavy chain family member 4
NCBI Official Symbol:ITIH4  
NCBI Official Synonym Symbols:H4P; IHRP; GP120; PK120; ITIHL1; PK-120; ITI-HC4  
NCBI Protein Information:inter-alpha-trypsin inhibitor heavy chain H4
UniProt Protein Name:Inter-alpha-trypsin inhibitor heavy chain H4
UniProt Synonym Protein Names:Inter-alpha-trypsin inhibitor family heavy chain-related protein; IHRP
Protein Family:Inter alpha-trypsin inhibitor
UniProt Gene Name:ITIH4  
UniProt Entry Name:ITIH4_HUMAN
Anti-ITIH4 Antibody (CAB12807)Western blot analysis of extracts of various cell lines, using ITIH4 antibody (CAB12807) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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