Signal Transduction Antibodies 3
Anti-ITIH3 Antibody (CAB9459)
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- SKU:
- CAB9459
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-ITIH3 Antibody |
| Antibody SKU: | CAB9459 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-180 of human ITIH3 (NP_002208.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, 293T, NCI-H460, Mouse liver, Mouse lung, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-180 of human ITIH3 (NP_002208.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LPEG VANG IEVY STKI NSKV TSRF AHNV VTMR AVNR ADTA KEVS FDVE LPKT AFIT NFTL TIDG VTYP GNVK EKEV AKKQ YEKA VSQG KTAG LVKA SGRK LEKF TVSV NVAA GSKV TFEL TYEE LLKR HKGK YEMY LKVQ PKQL VK |
| Gene ID: | 3699 |
| Uniprot: | Q06033 |
| Cellular Location: | Secreted |
| Calculated MW: | 99kDa |
| Observed MW: | 105kDa |
| Synonyms: | ITIH3, H3P, ITI-HC3, SHAP |
| Background: | This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. Polymorphisms of this gene may be associated with increased risk for schizophrenia and major depressive disorder. This gene is present in an inter-alpha-trypsin inhibitor family gene cluster on chromosome 3. |
| UniProt Protein Function: | ITIH3: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Belongs to the ITIH family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Inhibitor Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: extracellular region Molecular Function:serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity Biological Process: hyaluronan metabolic process |
| NCBI Summary: | The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009] |
| UniProt Code: | Q06033 |
| NCBI GenInfo Identifier: | 133925809 |
| NCBI Gene ID: | 3699 |
| NCBI Accession: | NP_002208.3 |
| UniProt Secondary Accession: | Q06033,Q3B7H5, Q53F06, Q6LAM2, Q99085, |
| UniProt Related Accession: | Q06033 |
| Molecular Weight: | 99,849 Da |
| NCBI Full Name: | inter-alpha-trypsin inhibitor heavy chain H3 preproprotein |
| NCBI Synonym Full Names: | inter-alpha-trypsin inhibitor heavy chain 3 |
| NCBI Official Symbol: | ITIH3 |
| NCBI Official Synonym Symbols: | H3P |
| NCBI Protein Information: | inter-alpha-trypsin inhibitor heavy chain H3; SHAP; ITI-HC3; ITI heavy chain H3; inter-alpha (globulin) inhibitor H3; inter-alpha-inhibitor heavy chain 3; serum-derived hyaluronan-associated protein; pre-alpha (globulin) inhibitor, H3 polypeptide; inter-alpha (globulin) inhibitor, H3 polypeptide |
| UniProt Protein Name: | Inter-alpha-trypsin inhibitor heavy chain H3 |
| UniProt Synonym Protein Names: | Serum-derived hyaluronan-associated protein; SHAP |
| Protein Family: | Inter-alpha-trypsin inhibitor |
| UniProt Gene Name: | ITIH3 |
| UniProt Entry Name: | ITIH3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ITIH3 antibody (CAB9459) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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