Cell Biology Antibodies 2

Anti-ITIH1 Antibody (CAB10833)

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SKU:
CAB10833
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ITIH1 Antibody
Antibody SKU:CAB10833
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 530-670 of human ITIH1 (NP_002206.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:LO2, heLa, U-251MG, 293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 530-670 of human ITIH1 (NP_002206.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HGEG QEFS ITCL VDEE EMKK LLRE RGHM LENH VERL WAYL TIQE LLAK RMKV DREE RANL SSQA LQMS LDYG FVTP LTSM SIRG MADQ DGLK PTID KPSE DSPP LEML GPRR TFVL SALQ PSPT HSSS NTQR LPDR VTGV D
Gene ID:3697
Uniprot:P19827
Cellular Location:Secreted
Calculated MW:69kDa/86kDa/101kDa
Observed MW:115kDa
Synonyms:ITIH1, H1P, IATIH, IGHEP1, ITI-HC1, ITIH, SHAP
Background:This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3.
UniProt Protein Function:ITIH1: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Belongs to the ITIH family.
UniProt Protein Details:

Protein type:Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3p21.1

Molecular Function:calcium ion binding

NCBI Summary:This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015]
UniProt Code:P19827
NCBI GenInfo Identifier:2851501
NCBI Gene ID:3697
NCBI Accession:P19827.3
UniProt Secondary Accession:P19827,P78455, Q01746, Q562G1, A8K9N5, B2RAH9, B7Z558 B7Z8C0, F5H165, F5H7Y8,
UniProt Related Accession:P19827
Molecular Weight:101kDa
NCBI Full Name:Inter-alpha-trypsin inhibitor heavy chain H1
NCBI Synonym Full Names:inter-alpha-trypsin inhibitor heavy chain 1
NCBI Official Symbol:ITIH1  
NCBI Official Synonym Symbols:H1P; ITIH; SHAP; IATIH; IGHEP1; ITI-HC1  
NCBI Protein Information:inter-alpha-trypsin inhibitor heavy chain H1
UniProt Protein Name:Inter-alpha-trypsin inhibitor heavy chain H1
UniProt Synonym Protein Names:Inter-alpha-trypsin inhibitor complex component III; Serum-derived hyaluronan-associated protein; SHAP
Protein Family:Inter-alpha-trypsin inhibitor
UniProt Gene Name:ITIH1  
Anti-ITIH1 Antibody (CAB10833)Western blot analysis of extracts of various cell lines, using ITIH1 antibody (CAB10833) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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