Name: Anti-ITGB7 Antibody (CAB5873)
Brand: Cell Biology Antibodies 9
SKU: CAB5873
Availability: OutOfStock

Antibody Name:	Anti-ITGB7 Antibody
Antibody SKU:	CAB5873
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human ITGB7 (NP_000880.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	HT-29, THP-1, LO2, Mouse lung, Mouse thymus

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human ITGB7 (NP_000880.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MVAL PMVL VLLL VLSR GESE LDAK IPST GDAT EWRN PHLS MLGS CQPA PSCQ KCIL SHPS CAWC KQLN FTAS GEAE ARRC ARRE ELLA RGCP LEEL EEPR GQQE VLQD QPLS QGAR GEGA TQLA PQRV RVTL RPGE PQQL
Gene ID:	3695
Uniprot:	P26010
Cellular Location:	Membrane, Single-pass type I membrane protein
Calculated MW:	71kDa/86kDa
Observed MW:	87kDa

Synonyms:

ITGB7

Background:

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

UniProt Protein Function:	ITGB7: integrin alpha-4/beta-7 (Peyer's patches-specific homing receptor lpam-1) is expected to play a role in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM 1. Integrin alpha-e/beta-7 (HML-1) is a receptor for e-cadherin. Two alternatively spliced isoforms have been described.
UniProt Protein Details:	Protein type:Receptor, misc.; Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: cell surface; membrane; plasma membrane; integrin complex; receptor complex Molecular Function:viral receptor activity; protein binding; metal ion binding; cell adhesion molecule binding Biological Process: integrin-mediated signaling pathway; heterotypic cell-cell adhesion; extracellular matrix organization and biogenesis; regulation of immune response; entry of virus into host cell; multicellular organismal development; cell-matrix adhesion; cell adhesion; leukocyte tethering or rolling; receptor clustering
NCBI Summary:	This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
UniProt Code:	P26010
NCBI GenInfo Identifier:	124973
NCBI Gene ID:	3695
NCBI Accession:	P26010.1
UniProt Secondary Accession:	P26010,Q9UCP7, Q9UCS7,
UniProt Related Accession:	P26010
Molecular Weight:	798
NCBI Full Name:	Integrin beta-7
NCBI Synonym Full Names:	integrin, beta 7
NCBI Official Symbol:	ITGB7
NCBI Protein Information:	integrin beta-7; integrin beta 7 subunit; gut homing receptor beta subunit
UniProt Protein Name:	Integrin beta-7
UniProt Synonym Protein Names:	Gut homing receptor beta subunit
Protein Family:	Integrin
UniProt Gene Name:	ITGB7
UniProt Entry Name:	ITB7_HUMAN

Western blot analysis of extracts of various cell lines, using ITGB7 antibody (CAB5873) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

Antibodies

ITGB7 Antibody (PACO10012)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)