Cell Biology Antibodies 7

Anti-ITGB6 Antibody (CAB16904)

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SKU:
CAB16904
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ITGB6 Antibody
Antibody SKU:CAB16904
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 732-788 of human ITGB6 (NP_000879.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 732-788 of human ITGB6 (NP_000879.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLVS FHDR KEVA KFEA ERSK AKWQ TGTN PLYR GSTS TFKN VTYK HREK QKVD LSTD C
Gene ID:3694
Uniprot:P18564
Cellular Location:
Calculated MW:74kDa/85kDa
Observed MW:Refer to figures
Synonyms:ITGB6, AI1H
Background:This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881).
NCBI Summary:This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Code:P18564
NCBI GenInfo Identifier:9625002
NCBI Gene ID:3694
NCBI Accession:NP_000879.2
UniProt Secondary Accession:P18564,Q0VA95, Q16500, Q53RG5, Q53RR6, B2R9W5, C9JA97
UniProt Related Accession:P18564
Molecular Weight:86
NCBI Full Name:integrin beta-6 isoform a
NCBI Synonym Full Names:integrin subunit beta 6
NCBI Official Symbol:ITGB6  
NCBI Official Synonym Symbols:AI1H  
NCBI Protein Information:integrin beta-6
UniProt Protein Name:Integrin beta-6
UniProt Gene Name:ITGB6  
Anti-ITGB6 Antibody (CAB16904)Western blot analysis of extracts of various cell lines, using ITGB6 antibody (CAB16904) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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