Cell Biology Antibodies 8

Anti-ITGB5 Antibody (CAB2497)

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SKU:
CAB2497
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ITGB5 Antibody
Antibody SKU:CAB2497
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 490-720 of human ITGB5 (NP_002204.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Mouse kidney, Mouse liver, Rat brain, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 490-720 of human ITGB5 (NP_002204.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SPGY LGTR CECQ DGEN QSVY QNLC REAE GKPL CSGR GDCS CNQC SCFE SEFG KIYG PFCE CDNF SCAR NKGV LCSG HGEC HCGE CKCH AGYI GDNC NCST DIST CRGR DGQI CSER GHCL CGQC QCTE PGAF GEMC EKCP TCPD ACST KRDC VECL LLHS GKPD NQTC HSLC RDEV ITWV DTIV KDDQ EAVL CFYK TAKD CVMM FTYV ELPS GKSN LTVL REPE CGNT PNA
Gene ID:3693
Uniprot:P18084
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:88kDa
Observed MW:92kDa
Synonyms:ITGB5
Background:
UniProt Protein Function:ITGB5: Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10. Belongs to the integrin beta chain family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 3q21.2

Cellular Component: cell surface; focal adhesion; phagocytic vesicle; plasma membrane; receptor complex

Molecular Function:protein binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell-matrix adhesion; extracellular matrix organization and biogenesis; integrin-mediated signaling pathway; muscle contraction; stress fiber formation; transforming growth factor beta receptor signaling pathway

UniProt Code:P18084
NCBI GenInfo Identifier:124970
NCBI Gene ID:3693
NCBI Accession:P18084.1
UniProt Secondary Accession:P18084,B0LPF8, B2RD70,
UniProt Related Accession:P18084
Molecular Weight:88,054 Da
NCBI Full Name:Integrin beta-5
NCBI Synonym Full Names:integrin subunit beta 5
NCBI Official Symbol:ITGB5  
NCBI Protein Information:integrin beta-5
UniProt Protein Name:Integrin beta-5
Protein Family:Integrin
UniProt Gene Name:ITGB5  
UniProt Entry Name:ITB5_HUMAN
Anti-ITGB5 Antibody (CAB2497)Western blot analysis of extracts of various cell lines, using ITGB5 antibody (CAB2497) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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