Cell Biology Antibodies 4

Anti-ITGA7 Antibody (CAB14246)

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SKU:
CAB14246
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ITGA7 Antibody
Antibody SKU:CAB14246
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 880-1020 of human ITGA7 (NP_002197.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-87MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 880-1020 of human ITGA7 (NP_002197.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QVEL EGGQ GPGQ KGLC SPRP NILH LDVD SRDR RRRE LEPP EQQE PGER QEPS MSWW PVSS AEKK KNIT LDCA RGTA NCVV FSCP LYSF DRAA VLHV WGRL WNST FLEE YSAV KSLE VIVR ANIT VKSS IKNL MLRD ASTV I
Gene ID:3679
Uniprot:Q13683
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:114kDa/121kDa/124kDa/126kDa/128kDa
Observed MW:140kDa
Synonyms:ITGA7
Background:The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
UniProt Protein Function:ITGA7: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Defects in ITGA7 are the cause of muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI). A form of congenital muscular dystrophy. Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with joint contractures. Belongs to the integrin alpha chain family. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: muscle tendon junction; cell surface; cytoplasm; plasma membrane; neuromuscular junction; sarcolemma

Molecular Function:integrin binding; protein heterodimerization activity; metal ion binding; laminin binding

Biological Process: integrin-mediated signaling pathway; regulation of cell shape; heterotypic cell-cell adhesion; muscle development; cell migration; skeletal muscle development; extracellular matrix organization and biogenesis; cell-matrix adhesion; blood vessel morphogenesis

Disease: Muscular Dystrophy, Congenital, Due To Integrin Alpha-7 Deficiency

NCBI Summary:The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009]
UniProt Code:Q13683
NCBI GenInfo Identifier:222418611
NCBI Gene ID:3679
NCBI Accession:NP_002197.2
UniProt Secondary Accession:Q13683,O43197, Q86W93, Q9NY89, Q9UET0, Q9UEV2, B4E3U0 C9JMD3, C9JMZ6,
UniProt Related Accession:Q13683
Molecular Weight:114,545 Da
NCBI Full Name:integrin alpha-7 isoform 2
NCBI Synonym Full Names:integrin, alpha 7
NCBI Official Symbol:ITGA7  
NCBI Protein Information:integrin alpha-7; integrin alpha 7 chain
UniProt Protein Name:Integrin alpha-7
Protein Family:Integrin
UniProt Gene Name:ITGA7  
UniProt Entry Name:ITA7_HUMAN
Anti-ITGA7 Antibody (CAB14246)Western blot analysis of extracts of U-87MG cells, using ITGA7 antibody (CAB14246) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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