Name: Anti-ITGA3 Antibody (CAB17502)
Brand: Cell Biology Antibodies 13
SKU: CAB17502
Availability: OutOfStock

Antibody Name:	Anti-ITGA3 Antibody
Antibody SKU:	CAB17502
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein of Human ITGA3.

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	Mouse kidney, Mouse lung, Rat lung, A-431, PC-3, A-549

Immunogen:	Recombinant fusion protein of Human ITGA3.
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	3675
Uniprot:	P26006
Cellular Location:
Calculated MW:	116kDa/118kDa
Observed MW:	125kDa/130kDa

Western blot - ITGA3 Polyclonal Antibody (CAB17502)

Synonyms:

CD49C, FRP-2, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a, ITGA3

Background:

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]

UniProt Protein Function:	Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
NCBI Summary:	The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]
UniProt Code:	P26006
NCBI GenInfo Identifier:	347595830
NCBI Gene ID:	3675
NCBI Accession:	P26006.5
UniProt Secondary Accession:	P26006,A7E246, B7ZM80, B9EGQ1, D3DTX4, D3DTX5,
UniProt Related Accession:	P26006
Molecular Weight:
NCBI Full Name:	Integrin alpha-3
NCBI Synonym Full Names:	integrin subunit alpha 3
NCBI Official Symbol:	ITGA3
NCBI Official Synonym Symbols:	VL3A; CD49C; FRP-2; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3
NCBI Protein Information:	integrin alpha-3
UniProt Protein Name:	Integrin alpha-3
UniProt Synonym Protein Names:	CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3
Protein Family:	Integrin
UniProt Gene Name:	ITGA3
UniProt Entry Name:	ITA3_HUMAN