Cell Biology Antibodies 13

Anti-ITGA3 Antibody (CAB17502)

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SKU:
CAB17502
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ITGA3 Antibody
Antibody SKU:CAB17502
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein of Human ITGA3.
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse kidney, Mouse lung, Rat lung, A-431, PC-3, A-549
Immunogen:Recombinant fusion protein of Human ITGA3.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3675
Uniprot:P26006
Cellular Location:
Calculated MW:116kDa/118kDa
Observed MW:125kDa/130kDa
Anti-ITGA3 Antibody (CAB17502)Western blot - ITGA3 Polyclonal Antibody (CAB17502)
Synonyms:CD49C, FRP-2, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a, ITGA3
Background:The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]
UniProt Protein Function:Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
NCBI Summary:The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]
UniProt Code:P26006
NCBI GenInfo Identifier:347595830
NCBI Gene ID:3675
NCBI Accession:P26006.5
UniProt Secondary Accession:P26006,A7E246, B7ZM80, B9EGQ1, D3DTX4, D3DTX5,
UniProt Related Accession:P26006
Molecular Weight:
NCBI Full Name:Integrin alpha-3
NCBI Synonym Full Names:integrin subunit alpha 3
NCBI Official Symbol:ITGA3  
NCBI Official Synonym Symbols:VL3A; CD49C; FRP-2; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3  
NCBI Protein Information:integrin alpha-3
UniProt Protein Name:Integrin alpha-3
UniProt Synonym Protein Names:CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3
Protein Family:Integrin
UniProt Gene Name:ITGA3  
UniProt Entry Name:ITA3_HUMAN
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