Cell Biology Antibodies 9
Anti-ITGA2B Antibody (CAB5680)
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- SKU:
- CAB5680
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ITGA2B Antibody |
| Antibody SKU: | CAB5680 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 693-993 of human ITGA2B (NP_000410.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 693-993 of human ITGA2B (NP_000410.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ALSN VEGF ERLI CNQK KENE TRVV LCEL GNPM KKNA QIGI AMLV SVGN LEEA GESV SFQL QIRS KNSQ NPNS KIVL LDVP VRAE AQVE LRGN SFPA SLVV AAEE GERE QNSL DSWG PKVE HTYE LHNN GPGT VNGL HLSI HLPG QSQP SDLL YILD IQPQ GGLQ CFPQ PPVN PLKV DWGL PIPS PSPI HPAH HKRD RRQI FLPE PEQP SRLQ DPVL VSCD SAPC TVVQ CDLQ EMAR GQRA MVTV LAFL WLPS LYQR PLDQ FVLQ SHAW FNVS SLPY AVPP LSLP RGEA QVWT QLLR ALEE R |
| Gene ID: | 3674 |
| Uniprot: | P08514 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 103kDa/109kDa/113kDa |
| Observed MW: | 135kDa |
| Synonyms: | ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93 |
| Background: | This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. |
| UniProt Protein Function: | ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q21.31 Cellular Component: cell surface; integral to plasma membrane; plasma membrane; platelet alpha granule membrane Molecular Function:identical protein binding; protein binding Biological Process: cell adhesion; extracellular matrix organization and biogenesis; integrin-mediated signaling pathway; platelet degranulation Disease: Bleeding Disorder, Platelet-type, 16; Glanzmann Thrombasthenia |
| NCBI Summary: | This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P08514 |
| NCBI GenInfo Identifier: | 226694183 |
| NCBI Gene ID: | 3674 |
| NCBI Accession: | P08514.3 |
| UniProt Secondary Accession: | P08514,O95366, Q14443, Q17R67, B2RCY8, |
| UniProt Related Accession: | P08514 |
| Molecular Weight: | 113kDa |
| NCBI Full Name: | Integrin alpha-IIb |
| NCBI Synonym Full Names: | integrin subunit alpha 2b |
| NCBI Official Symbol: | ITGA2B |
| NCBI Official Synonym Symbols: | GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93 |
| NCBI Protein Information: | integrin alpha-IIb |
| UniProt Protein Name: | Integrin alpha-IIb |
| UniProt Synonym Protein Names: | GPalpha IIb; GPIIb |
| Protein Family: | Integrin |
| UniProt Gene Name: | ITGA2B |
 | Western blot analysis of extracts of mouse liver, using ITGA2B antibody (CAB5680) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of U2OS cells using ITGA2B antibody (CAB5680). Blue: DAPI for nuclear staining. |
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