Metabolism Antibodies 3

Anti-ISYNA1 Antibody (CAB8965)

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SKU:
CAB8965
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism

Description

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Antibody Name:Anti-ISYNA1 Antibody
Antibody SKU:CAB8965
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ISYNA1 (NP_057452.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ISYNA1 (NP_057452.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEAA AQFF VESP DVVY GPEA IEAQ YEYR TTRV SREG GVLK VHPT STRF TFRT ARQV PRLG VMLV GWGG NNGS TLTA AVLA NRLR LSWP TRSG RKEA NYYG SLTQ AGTV SLGL DAEG QEVF VPFS AVLP MVAP NDLV FDGW DISS LNLA EAMR RAKV LDWG LQEQ LWPH MEAL RPRP SVYI PEFI AANQ SARA DNLI PGSR AQQL EQIR RDIR DFRS SAGL DKVI VLWT ANTE RFCE VIPG LNDT AENL LR
Gene ID:51477
Uniprot:Q9NPH2
Cellular Location:Cytoplasm
Calculated MW:47kDa/55kDa/61kDa
Observed MW:61kDa
Synonyms:ISYNA1, INO1, INOS, IPS, IPS 1, IPS-1, IPS1
Background:This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4.
UniProt Protein Function:ISYNA1: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds. Belongs to the myo-inositol 1-phosphate synthase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 5.5.1.4; Isomerase; Carbohydrate Metabolism - inositol phosphate

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: cytosol

Molecular Function:inositol-3-phosphate synthase activity; protein binding

Biological Process: inositol phosphate metabolic process

NCBI Summary:This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
UniProt Code:Q9NPH2
NCBI GenInfo Identifier:74734304
NCBI Gene ID:51477
NCBI Accession:Q9NPH2.1
UniProt Secondary Accession:Q9NPH2,Q6NXT5, Q7Z525, Q9BT65, Q9H2Y2, Q9NSU0, Q9NVW7 B3KRT1, G5E9U0,
UniProt Related Accession:Q9NPH2
Molecular Weight:55,136 Da
NCBI Full Name:Inositol-3-phosphate synthase 1
NCBI Synonym Full Names:inositol-3-phosphate synthase 1
NCBI Official Symbol:ISYNA1  
NCBI Official Synonym Symbols:IPS; INO1; INOS; IPS 1; IPS-1  
NCBI Protein Information:inositol-3-phosphate synthase 1
UniProt Protein Name:Inositol-3-phosphate synthase 1
UniProt Synonym Protein Names:Myo-inositol 1-phosphate synthase; MI-1-P synthase; MIP synthase; hIPS; Myo-inositol 1-phosphate synthase A1; hINO1
Protein Family:Inositol-3-phosphate synthase
UniProt Gene Name:ISYNA1  
UniProt Entry Name:INO1_HUMAN
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