Metabolism Antibodies 3
Anti-ISYNA1 Antibody (CAB8965)
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- SKU:
- CAB8965
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-ISYNA1 Antibody |
| Antibody SKU: | CAB8965 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ISYNA1 (NP_057452.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ISYNA1 (NP_057452.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEAA AQFF VESP DVVY GPEA IEAQ YEYR TTRV SREG GVLK VHPT STRF TFRT ARQV PRLG VMLV GWGG NNGS TLTA AVLA NRLR LSWP TRSG RKEA NYYG SLTQ AGTV SLGL DAEG QEVF VPFS AVLP MVAP NDLV FDGW DISS LNLA EAMR RAKV LDWG LQEQ LWPH MEAL RPRP SVYI PEFI AANQ SARA DNLI PGSR AQQL EQIR RDIR DFRS SAGL DKVI VLWT ANTE RFCE VIPG LNDT AENL LR |
| Gene ID: | 51477 |
| Uniprot: | Q9NPH2 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 47kDa/55kDa/61kDa |
| Observed MW: | 61kDa |
| Synonyms: | ISYNA1, INO1, INOS, IPS, IPS 1, IPS-1, IPS1 |
| Background: | This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4. |
| UniProt Protein Function: | ISYNA1: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds. Belongs to the myo-inositol 1-phosphate synthase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 5.5.1.4; Isomerase; Carbohydrate Metabolism - inositol phosphate Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: cytosol Molecular Function:inositol-3-phosphate synthase activity; protein binding Biological Process: inositol phosphate metabolic process |
| NCBI Summary: | This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9NPH2 |
| NCBI GenInfo Identifier: | 74734304 |
| NCBI Gene ID: | 51477 |
| NCBI Accession: | Q9NPH2.1 |
| UniProt Secondary Accession: | Q9NPH2,Q6NXT5, Q7Z525, Q9BT65, Q9H2Y2, Q9NSU0, Q9NVW7 B3KRT1, G5E9U0, |
| UniProt Related Accession: | Q9NPH2 |
| Molecular Weight: | 55,136 Da |
| NCBI Full Name: | Inositol-3-phosphate synthase 1 |
| NCBI Synonym Full Names: | inositol-3-phosphate synthase 1 |
| NCBI Official Symbol: | ISYNA1 |
| NCBI Official Synonym Symbols: | IPS; INO1; INOS; IPS 1; IPS-1 |
| NCBI Protein Information: | inositol-3-phosphate synthase 1 |
| UniProt Protein Name: | Inositol-3-phosphate synthase 1 |
| UniProt Synonym Protein Names: | Myo-inositol 1-phosphate synthase; MI-1-P synthase; MIP synthase; hIPS; Myo-inositol 1-phosphate synthase A1; hINO1 |
| Protein Family: | Inositol-3-phosphate synthase |
| UniProt Gene Name: | ISYNA1 |
| UniProt Entry Name: | INO1_HUMAN |
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