Immunology Antibodies 1
Anti-ISG20 Antibody (CAB14744)
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- SKU:
- CAB14744
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-ISG20 Antibody |
| Antibody SKU: | CAB14744 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human ISG20 (NP_002192.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji, A-549, MCF7, Mouse spleen, Rat spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human ISG20 (NP_002192.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAGS REVV AMDC EMVG LGPH RESG LARC SLVN VHGA VLYD KFIR PEGE ITDY RTRV SGVT PQHM VGAT PF |
| Gene ID: | 3669 |
| Uniprot: | Q96AZ6 |
| Cellular Location: | Cajal body, Cytoplasm, Nucleus, nucleolus |
| Calculated MW: | 9kDa/20kDa |
| Observed MW: | 20kDa |
| Synonyms: | ISG20, CD25, HEM45 |
| Background: |
| UniProt Protein Function: | ISG20: Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses. Belongs to the exonuclease superfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleolus; Ribonuclease; Deoxyribonuclease; EC 3.1.13.1 Chromosomal Location of Human Ortholog: 15q26 Cellular Component: Cajal body; cytoplasm; nucleolus; nucleoplasm; nucleus; PML body Molecular Function:3'-5'-exoribonuclease activity; exonuclease activity; single-stranded DNA specific 3'-5' exodeoxyribonuclease activity; U1 snRNA binding; U2 snRNA binding Biological Process: cell proliferation; defense response to virus; DNA catabolic process, exonucleolytic; negative regulation of viral genome replication; response to virus; RNA catabolic process |
| UniProt Code: | Q96AZ6 |
| NCBI GenInfo Identifier: | 57012967 |
| NCBI Gene ID: | 3669 |
| NCBI Accession: | Q96AZ6.2 |
| UniProt Secondary Accession: | Q96AZ6,O00441, O00586, |
| UniProt Related Accession: | Q96AZ6 |
| Molecular Weight: | 9,199 Da |
| NCBI Full Name: | Interferon-stimulated gene 20 kDa protein |
| NCBI Synonym Full Names: | interferon stimulated exonuclease gene 20 |
| NCBI Official Symbol: | ISG20 |
| NCBI Official Synonym Symbols: | CD25; HEM45 |
| NCBI Protein Information: | interferon-stimulated gene 20 kDa protein |
| UniProt Protein Name: | Interferon-stimulated gene 20 kDa protein |
| UniProt Synonym Protein Names: | Estrogen-regulated transcript 45 protein; Promyelocytic leukemia nuclear body-associated protein ISG20 |
| Protein Family: | Interferon-stimulated gene 20 kDa protein |
| UniProt Gene Name: | ISG20 |
| UniProt Entry Name: | ISG20_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ISG20 antibody (CAB14744) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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