Cell Biology Antibodies 15
Anti-IRX3 Antibody (CAB17765)
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- SKU:
- CAB17765
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-IRX3 Antibody |
| Antibody SKU: | CAB17765 |
| Antibody Size: | 20uL, 50 uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human IRX3 (NP_077312.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human IRX3 (NP_077312.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SNVL SSVY GAPY AAAA AAAA AQGY GAFL PYAA ELPI FPQL GAQY ELKD SPGV QHPA AAAA FPHP HPAF YPYG QYQF GDPS RPKN ATRE STST LKAW LNEH R |
| Gene ID: | 79191 |
| Uniprot: | P78415 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | IRX-1, IRXB1, IRX3 |
| Background: | IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009] |
| UniProt Protein Function: | IRX3: Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Belongs to the TALE/IRO homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 16q12.2 |
| NCBI Summary: | IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009] |
| UniProt Code: | P78415 |
| NCBI GenInfo Identifier: | 47117874 |
| NCBI Gene ID: | 79191 |
| NCBI Accession: | P78415.3 |
| UniProt Secondary Accession: | P78415,Q7Z4A4, Q7Z4A5, Q8IVC6, |
| UniProt Related Accession: | P78415 |
| Molecular Weight: | 52,119 Da |
| NCBI Full Name: | Iroquois-class homeodomain protein IRX-3 |
| NCBI Synonym Full Names: | iroquois homeobox 3 |
| NCBI Official Symbol: | IRX3 |
| NCBI Official Synonym Symbols: | IRX-1; IRXB1 |
| NCBI Protein Information: | iroquois-class homeodomain protein IRX-3 |
| UniProt Protein Name: | Iroquois-class homeodomain protein IRX-3 |
| UniProt Synonym Protein Names: | Homeodomain protein IRXB1; Iroquois homeobox protein 3 |
| Protein Family: | Iroquois-class homeodomain protein |
| UniProt Gene Name: | IRX3 |
| UniProt Entry Name: | IRX3_HUMAN |
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